Slide
Centre Interdisciplinaire
de Recherche et d’Innovation
en Cybersécurité et Société
de Recherche et d’Innovation
en Cybersécurité et Société
1.
Fareedi, A. A.; Gagnon, S.; Ghazawneh, A.; Valverde, R.
Semantic Fusion of Health Data: Implementing a Federated Virtualized Knowledge Graph Framework Leveraging Ontop System Journal Article
In: Future Internet, vol. 17, no. 6, 2025, ISSN: 19995903 (ISSN), (Publisher: Multidisciplinary Digital Publishing Institute (MDPI)).
Abstract | Links | BibTeX | Tags: Data integration, Data interoperability, Federated information systems, Federated ontology, Graph framework, Interoperability, Knowledge graphs, Knowledge management, Medical computing, Ontology, Ontology's, Ontop, Query processing, Semantic interoperability, Semantic Web, Semantics, Virtual knowledge, virtual reality, Virtualization, Virtualized knowledge graph
@article{fareedi_semantic_2025,
title = {Semantic Fusion of Health Data: Implementing a Federated Virtualized Knowledge Graph Framework Leveraging Ontop System},
author = {A. A. Fareedi and S. Gagnon and A. Ghazawneh and R. Valverde},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105009278332&doi=10.3390%2ffi17060245&partnerID=40&md5=72bd14d033887f72e7e0c8a6a1451415},
doi = {10.3390/fi17060245},
issn = {19995903 (ISSN)},
year = {2025},
date = {2025-01-01},
journal = {Future Internet},
volume = {17},
number = {6},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
abstract = {Data integration (DI) and semantic interoperability (SI) are critical in healthcare, enabling seamless, patient-centric data sharing across systems to meet the demand for instant, unambiguous access to health information. Federated information systems (FIS) highlight auspicious issues for seamless DI and SI stemming from diverse data sources or models. We present a hybrid ontology-based design science research engineering (ODSRE) methodology that combines design science activities with ontology engineering principles to address the above-mentioned issues. The ODSRE constructs a systematic mechanism leveraging the Ontop virtual paradigm to establish a state-of-the-art federated virtual knowledge graph framework (FVKG) embedded virtualized knowledge graph approach to mitigate the aforementioned challenges effectively. The proposed FVKG helps construct a virtualized data federation leveraging the Ontop semantic query engine that effectively resolves data bottlenecks. Using a virtualized technique, the FVKG helps to reduce data migration, ensures low latency and dynamic freshness, and facilitates real-time access while upholding integrity and coherence throughout the federation system. As a result, we suggest a customized framework for constructing ontological monolithic semantic artifacts, especially in FIS. The proposed FVKG incorporates ontology-based data access (OBDA) to build a monolithic virtualized repository that integrates various ontological-driven artifacts and ensures semantic alignments using schema mapping techniques. © 2025 by the authors.},
note = {Publisher: Multidisciplinary Digital Publishing Institute (MDPI)},
keywords = {Data integration, Data interoperability, Federated information systems, Federated ontology, Graph framework, Interoperability, Knowledge graphs, Knowledge management, Medical computing, Ontology, Ontology's, Ontop, Query processing, Semantic interoperability, Semantic Web, Semantics, Virtual knowledge, virtual reality, Virtualization, Virtualized knowledge graph},
pubstate = {published},
tppubtype = {article}
}
Data integration (DI) and semantic interoperability (SI) are critical in healthcare, enabling seamless, patient-centric data sharing across systems to meet the demand for instant, unambiguous access to health information. Federated information systems (FIS) highlight auspicious issues for seamless DI and SI stemming from diverse data sources or models. We present a hybrid ontology-based design science research engineering (ODSRE) methodology that combines design science activities with ontology engineering principles to address the above-mentioned issues. The ODSRE constructs a systematic mechanism leveraging the Ontop virtual paradigm to establish a state-of-the-art federated virtual knowledge graph framework (FVKG) embedded virtualized knowledge graph approach to mitigate the aforementioned challenges effectively. The proposed FVKG helps construct a virtualized data federation leveraging the Ontop semantic query engine that effectively resolves data bottlenecks. Using a virtualized technique, the FVKG helps to reduce data migration, ensures low latency and dynamic freshness, and facilitates real-time access while upholding integrity and coherence throughout the federation system. As a result, we suggest a customized framework for constructing ontological monolithic semantic artifacts, especially in FIS. The proposed FVKG incorporates ontology-based data access (OBDA) to build a monolithic virtualized repository that integrates various ontological-driven artifacts and ensures semantic alignments using schema mapping techniques. © 2025 by the authors.
2.
Mehrban, A.; Houda, Z. Abou El; Moudoud, H.; Bao, L. Le
Integrating Zero Trust Architecture in O-RAN: A Comprehensive Survey and Analysis Journal Article
In: IEEE Open Journal of the Communications Society, vol. 6, pp. 10465–10495, 2025, ISSN: 2644125X (ISSN).
Abstract | Links | BibTeX | Tags: 6g network, 6G networks, Access control, Data flow analysis, Intelligent controllers, Interoperability, Mobile telecommunication systems, Multi-vendor, Network architecture, Network components, Network security, New approaches, Open radio access network, open radio access network (O-RAN), Radio access networks, RAN intelligent controller, RAN intelligent controller (RIC), Smart contract, Survey and analysis, Trusted computing, Vendor interoperability, Zero trust architecture, Zero trust architecture (ZTA)
@article{mehrbanIntegratingZeroTrust2025,
title = {Integrating Zero Trust Architecture in O-RAN: A Comprehensive Survey and Analysis},
author = {A. Mehrban and Z. Abou El Houda and H. Moudoud and L. Le Bao},
url = {https://www.scopus.com/pages/publications/105025432034?origin=resultslist},
doi = {10.1109/OJCOMS.2025.3644132},
issn = {2644125X (ISSN)},
year = {2025},
date = {2025-01-01},
journal = {IEEE Open Journal of the Communications Society},
volume = {6},
pages = {10465–10495},
publisher = {Institute of Electrical and Electronics Engineers Inc.},
abstract = {Open Radio Access Network (O-RAN) is a new approach to mobile networks that disaggregates the network architecture into multi-vendor interoperable physical and software-defined network components connected through standardized open interfaces. This architecture enables deploying solutions on cloud-native platforms and boosting Artificial Intelligence(AI)-driven automation for network optimization. Despite the benefits of O-RAN’s heterogeneous and multi-vendor architecture, this approach inevitably enlarges the attack surface and introduces additional trust boundaries, which imminently threaten the uniformity of network performance. This also justifies the necessity of Zero Trust Architecture (ZTA) principles as a countermeasure, securing all network components, interfaces, and data flows. This survey shows how ZTA tenets can be integrated into O-RAN settings, contributing in three key areas: (1) a novel ZTA-to-O-RAN mapping model that explicitly places Policy Engine (PE), Policy Administrator (PA), and Policy Enforcement Points (PEPs) across RIC layers (Non-RT/Near-RT RIC), standardized interfaces (A1/E2/O1/O2), and disaggregated RAN functions (O-DU/O-CU/O-RU); (2) a Risk-Adaptive Access Control (RAdAC) framework that dynamically modulates verification depth based on contextual risk; and (3) integration of blockchain-based decentralized identity management with smart-contract-driven authorization for xApp/rApp lifecycle security. © 2020 IEEE.},
keywords = {6g network, 6G networks, Access control, Data flow analysis, Intelligent controllers, Interoperability, Mobile telecommunication systems, Multi-vendor, Network architecture, Network components, Network security, New approaches, Open radio access network, open radio access network (O-RAN), Radio access networks, RAN intelligent controller, RAN intelligent controller (RIC), Smart contract, Survey and analysis, Trusted computing, Vendor interoperability, Zero trust architecture, Zero trust architecture (ZTA)},
pubstate = {published},
tppubtype = {article}
}
Open Radio Access Network (O-RAN) is a new approach to mobile networks that disaggregates the network architecture into multi-vendor interoperable physical and software-defined network components connected through standardized open interfaces. This architecture enables deploying solutions on cloud-native platforms and boosting Artificial Intelligence(AI)-driven automation for network optimization. Despite the benefits of O-RAN’s heterogeneous and multi-vendor architecture, this approach inevitably enlarges the attack surface and introduces additional trust boundaries, which imminently threaten the uniformity of network performance. This also justifies the necessity of Zero Trust Architecture (ZTA) principles as a countermeasure, securing all network components, interfaces, and data flows. This survey shows how ZTA tenets can be integrated into O-RAN settings, contributing in three key areas: (1) a novel ZTA-to-O-RAN mapping model that explicitly places Policy Engine (PE), Policy Administrator (PA), and Policy Enforcement Points (PEPs) across RIC layers (Non-RT/Near-RT RIC), standardized interfaces (A1/E2/O1/O2), and disaggregated RAN functions (O-DU/O-CU/O-RU); (2) a Risk-Adaptive Access Control (RAdAC) framework that dynamically modulates verification depth based on contextual risk; and (3) integration of blockchain-based decentralized identity management with smart-contract-driven authorization for xApp/rApp lifecycle security. © 2020 IEEE.
3.
Fareedi, A. A.; Gagnon, S.; Ghazawneh, A.; Valverde, R.
Semantic Fusion of Health Data: Implementing a Federated Virtualized Knowledge Graph Framework Leveraging Ontop System Journal Article
In: Future Internet, vol. 17, no. 6, 2025, ISSN: 19995903 (ISSN).
Abstract | Links | BibTeX | Tags: Data integration, Data interoperability, Federated information systems, Federated ontology, Graph framework, Interoperability, Knowledge graphs, Knowledge management, Medical computing, Ontology, Ontology's, Ontop, Query processing, Semantic interoperability, Semantic Web, Semantics, Virtual knowledge, virtual reality, Virtualization, Virtualized knowledge graph
@article{fareediSemanticFusionHealth2025a,
title = {Semantic Fusion of Health Data: Implementing a Federated Virtualized Knowledge Graph Framework Leveraging Ontop System},
author = {A. A. Fareedi and S. Gagnon and A. Ghazawneh and R. Valverde},
url = {https://www.scopus.com/pages/publications/105009278332?origin=resultslist},
doi = {10.3390/fi17060245},
issn = {19995903 (ISSN)},
year = {2025},
date = {2025-01-01},
journal = {Future Internet},
volume = {17},
number = {6},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
abstract = {Data integration (DI) and semantic interoperability (SI) are critical in healthcare, enabling seamless, patient-centric data sharing across systems to meet the demand for instant, unambiguous access to health information. Federated information systems (FIS) highlight auspicious issues for seamless DI and SI stemming from diverse data sources or models. We present a hybrid ontology-based design science research engineering (ODSRE) methodology that combines design science activities with ontology engineering principles to address the above-mentioned issues. The ODSRE constructs a systematic mechanism leveraging the Ontop virtual paradigm to establish a state-of-the-art federated virtual knowledge graph framework (FVKG) embedded virtualized knowledge graph approach to mitigate the aforementioned challenges effectively. The proposed FVKG helps construct a virtualized data federation leveraging the Ontop semantic query engine that effectively resolves data bottlenecks. Using a virtualized technique, the FVKG helps to reduce data migration, ensures low latency and dynamic freshness, and facilitates real-time access while upholding integrity and coherence throughout the federation system. As a result, we suggest a customized framework for constructing ontological monolithic semantic artifacts, especially in FIS. The proposed FVKG incorporates ontology-based data access (OBDA) to build a monolithic virtualized repository that integrates various ontological-driven artifacts and ensures semantic alignments using schema mapping techniques. © 2025 by the authors.},
keywords = {Data integration, Data interoperability, Federated information systems, Federated ontology, Graph framework, Interoperability, Knowledge graphs, Knowledge management, Medical computing, Ontology, Ontology's, Ontop, Query processing, Semantic interoperability, Semantic Web, Semantics, Virtual knowledge, virtual reality, Virtualization, Virtualized knowledge graph},
pubstate = {published},
tppubtype = {article}
}
Data integration (DI) and semantic interoperability (SI) are critical in healthcare, enabling seamless, patient-centric data sharing across systems to meet the demand for instant, unambiguous access to health information. Federated information systems (FIS) highlight auspicious issues for seamless DI and SI stemming from diverse data sources or models. We present a hybrid ontology-based design science research engineering (ODSRE) methodology that combines design science activities with ontology engineering principles to address the above-mentioned issues. The ODSRE constructs a systematic mechanism leveraging the Ontop virtual paradigm to establish a state-of-the-art federated virtual knowledge graph framework (FVKG) embedded virtualized knowledge graph approach to mitigate the aforementioned challenges effectively. The proposed FVKG helps construct a virtualized data federation leveraging the Ontop semantic query engine that effectively resolves data bottlenecks. Using a virtualized technique, the FVKG helps to reduce data migration, ensures low latency and dynamic freshness, and facilitates real-time access while upholding integrity and coherence throughout the federation system. As a result, we suggest a customized framework for constructing ontological monolithic semantic artifacts, especially in FIS. The proposed FVKG incorporates ontology-based data access (OBDA) to build a monolithic virtualized repository that integrates various ontological-driven artifacts and ensures semantic alignments using schema mapping techniques. © 2025 by the authors.
4.
Mehrban, A.; Houda, Z. A. El; Moudoud, H.; Brik, B.; Khoukhi, L.
A Blockchain-Enabled Multi-Layered Zero-Trust Security Framework for O-RAN Proceedings Article
In: Int. Wirel. Commun. Mob. Comput. Conf., IWCMC, pp. 1564–1569, Institute of Electrical and Electronics Engineers Inc., 2025, ISBN: 979-833150887-6 (ISBN), (Journal Abbreviation: Int. Wirel. Commun. Mob. Comput. Conf., IWCMC).
Abstract | Links | BibTeX | Tags: Access control, Block-chain, Blockchain, Data privacy, Federated learning, federated learning (FL), Internet of thing, Internet of things, Internet of Things (IoT), Interoperability, Learning systems, Mobile telecommunication systems, Multi-layered, Network architecture, Network security, Open access, Open radio access network, open radio access network (O-RAN), Radio, Radio access networks, Radio access technologies, Radio communication, Secure communication, Security, Security frameworks, Security risks, Transfer learning, Trusted computing
@inproceedings{mehrbanBlockchainEnabledMultiLayeredZeroTrust2025,
title = {A Blockchain-Enabled Multi-Layered Zero-Trust Security Framework for O-RAN},
author = {A. Mehrban and Z. A. El Houda and H. Moudoud and B. Brik and L. Khoukhi},
url = {https://www.scopus.com/pages/publications/105011345211?origin=resultslist},
doi = {10.1109/IWCMC65282.2025.11059720},
isbn = {979-833150887-6 (ISBN)},
year = {2025},
date = {2025-01-01},
booktitle = {Int. Wirel. Commun. Mob. Comput. Conf., IWCMC},
pages = {1564–1569},
publisher = {Institute of Electrical and Electronics Engineers Inc.},
abstract = {O-RAN (Open Radio Access Network) is a set of open and interoperable radio access technologies, guided by the O-RAN Alliance, that, despite an open ecosystem, introduces significant security risks, expanding the threat surface in 6G networks. Traditional perimeter-based security approaches are inadequate for O-RAN's highly distributed, multi-vendor environments, where Zero Trust Architecture (ZTA) becomes essential for robust security. To address these challenges, we propose a novel blockchain-based, decentralized Zero-Trust Framework specifically designed for O-RAN security. Our proposed framework comprises two key layers: the first layer utilizes Federated Learning (FL) and Transfer Learning (TL) for advanced attack detection, enabling distributed, privacy-preserving threat analysis across O-RAN nodes. The second layer enforces Zero Trust access control through a blockchain-based identity management system, ensuring tamper-resistant, real-time policy updates. This multi-layered framework provides adaptive threat detection and resilient access control, validated through simulations demonstrating high detection accuracy and robust access management with minimal impact on network performance, offering a scalable security solution for next-generation O-RAN deployments. © 2025 IEEE.},
note = {Journal Abbreviation: Int. Wirel. Commun. Mob. Comput. Conf., IWCMC},
keywords = {Access control, Block-chain, Blockchain, Data privacy, Federated learning, federated learning (FL), Internet of thing, Internet of things, Internet of Things (IoT), Interoperability, Learning systems, Mobile telecommunication systems, Multi-layered, Network architecture, Network security, Open access, Open radio access network, open radio access network (O-RAN), Radio, Radio access networks, Radio access technologies, Radio communication, Secure communication, Security, Security frameworks, Security risks, Transfer learning, Trusted computing},
pubstate = {published},
tppubtype = {inproceedings}
}
O-RAN (Open Radio Access Network) is a set of open and interoperable radio access technologies, guided by the O-RAN Alliance, that, despite an open ecosystem, introduces significant security risks, expanding the threat surface in 6G networks. Traditional perimeter-based security approaches are inadequate for O-RAN's highly distributed, multi-vendor environments, where Zero Trust Architecture (ZTA) becomes essential for robust security. To address these challenges, we propose a novel blockchain-based, decentralized Zero-Trust Framework specifically designed for O-RAN security. Our proposed framework comprises two key layers: the first layer utilizes Federated Learning (FL) and Transfer Learning (TL) for advanced attack detection, enabling distributed, privacy-preserving threat analysis across O-RAN nodes. The second layer enforces Zero Trust access control through a blockchain-based identity management system, ensuring tamper-resistant, real-time policy updates. This multi-layered framework provides adaptive threat detection and resilient access control, validated through simulations demonstrating high detection accuracy and robust access management with minimal impact on network performance, offering a scalable security solution for next-generation O-RAN deployments. © 2025 IEEE.
5.
Fareedi, A. A.; Gagnon, S.; Ghazawneh, A.; Valverde, R.
Semantic Fusion of Health Data: Implementing a Federated Virtualized Knowledge Graph Framework Leveraging Ontop System Journal Article
In: Future Internet, vol. 17, no. 6, 2025, ISSN: 19995903 (ISSN).
Abstract | Links | BibTeX | Tags: Data integration, Data interoperability, Federated information systems, Federated ontology, Graph framework, Interoperability, Knowledge graphs, Knowledge management, Medical computing, Ontology, Ontology's, Ontop, Query processing, Semantic interoperability, Semantic Web, Semantics, Virtual knowledge, virtual reality, Virtualization, Virtualized knowledge graph
@article{fareediSemanticFusionHealth2025b,
title = {Semantic Fusion of Health Data: Implementing a Federated Virtualized Knowledge Graph Framework Leveraging Ontop System},
author = {A. A. Fareedi and S. Gagnon and A. Ghazawneh and R. Valverde},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105009278332&doi=10.3390%2Ffi17060245&partnerID=40&md5=8f53ce5a912bf16f4ac8bb24fb7338bf},
doi = {10.3390/fi17060245},
issn = {19995903 (ISSN)},
year = {2025},
date = {2025-01-01},
journal = {Future Internet},
volume = {17},
number = {6},
abstract = {Data integration (DI) and semantic interoperability (SI) are critical in healthcare, enabling seamless, patient-centric data sharing across systems to meet the demand for instant, unambiguous access to health information. Federated information systems (FIS) highlight auspicious issues for seamless DI and SI stemming from diverse data sources or models. We present a hybrid ontology-based design science research engineering (ODSRE) methodology that combines design science activities with ontology engineering principles to address the above-mentioned issues. The ODSRE constructs a systematic mechanism leveraging the Ontop virtual paradigm to establish a state-of-the-art federated virtual knowledge graph framework (FVKG) embedded virtualized knowledge graph approach to mitigate the aforementioned challenges effectively. The proposed FVKG helps construct a virtualized data federation leveraging the Ontop semantic query engine that effectively resolves data bottlenecks. Using a virtualized technique, the FVKG helps to reduce data migration, ensures low latency and dynamic freshness, and facilitates real-time access while upholding integrity and coherence throughout the federation system. As a result, we suggest a customized framework for constructing ontological monolithic semantic artifacts, especially in FIS. The proposed FVKG incorporates ontology-based data access (OBDA) to build a monolithic virtualized repository that integrates various ontological-driven artifacts and ensures semantic alignments using schema mapping techniques. © 2025 by the authors.},
keywords = {Data integration, Data interoperability, Federated information systems, Federated ontology, Graph framework, Interoperability, Knowledge graphs, Knowledge management, Medical computing, Ontology, Ontology's, Ontop, Query processing, Semantic interoperability, Semantic Web, Semantics, Virtual knowledge, virtual reality, Virtualization, Virtualized knowledge graph},
pubstate = {published},
tppubtype = {article}
}
Data integration (DI) and semantic interoperability (SI) are critical in healthcare, enabling seamless, patient-centric data sharing across systems to meet the demand for instant, unambiguous access to health information. Federated information systems (FIS) highlight auspicious issues for seamless DI and SI stemming from diverse data sources or models. We present a hybrid ontology-based design science research engineering (ODSRE) methodology that combines design science activities with ontology engineering principles to address the above-mentioned issues. The ODSRE constructs a systematic mechanism leveraging the Ontop virtual paradigm to establish a state-of-the-art federated virtual knowledge graph framework (FVKG) embedded virtualized knowledge graph approach to mitigate the aforementioned challenges effectively. The proposed FVKG helps construct a virtualized data federation leveraging the Ontop semantic query engine that effectively resolves data bottlenecks. Using a virtualized technique, the FVKG helps to reduce data migration, ensures low latency and dynamic freshness, and facilitates real-time access while upholding integrity and coherence throughout the federation system. As a result, we suggest a customized framework for constructing ontological monolithic semantic artifacts, especially in FIS. The proposed FVKG incorporates ontology-based data access (OBDA) to build a monolithic virtualized repository that integrates various ontological-driven artifacts and ensures semantic alignments using schema mapping techniques. © 2025 by the authors.
6.
Fareedi, A. A.; Gagnon, S.; Ghazawneh, A.; Valverde, R.
Semantic Fusion of Health Data: Implementing a Federated Virtualized Knowledge Graph Framework Leveraging Ontop System Journal Article
In: Future Internet, vol. 17, no. 6, 2025, ISSN: 19995903 (ISSN).
Abstract | Links | BibTeX | Tags: Data integration, Data interoperability, Federated information systems, Federated ontology, Graph framework, Interoperability, Knowledge graphs, Knowledge management, Medical computing, Ontology, Ontology's, Ontop, Query processing, Semantic interoperability, Semantic Web, Semantics, Virtual knowledge, virtual reality, Virtualization, Virtualized knowledge graph
@article{fareediSemanticFusionHealth2025,
title = {Semantic Fusion of Health Data: Implementing a Federated Virtualized Knowledge Graph Framework Leveraging Ontop System},
author = {A. A. Fareedi and S. Gagnon and A. Ghazawneh and R. Valverde},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105009278332&doi=10.3390%2ffi17060245&partnerID=40&md5=72bd14d033887f72e7e0c8a6a1451415},
doi = {10.3390/fi17060245},
issn = {19995903 (ISSN)},
year = {2025},
date = {2025-01-01},
journal = {Future Internet},
volume = {17},
number = {6},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
abstract = {Data integration (DI) and semantic interoperability (SI) are critical in healthcare, enabling seamless, patient-centric data sharing across systems to meet the demand for instant, unambiguous access to health information. Federated information systems (FIS) highlight auspicious issues for seamless DI and SI stemming from diverse data sources or models. We present a hybrid ontology-based design science research engineering (ODSRE) methodology that combines design science activities with ontology engineering principles to address the above-mentioned issues. The ODSRE constructs a systematic mechanism leveraging the Ontop virtual paradigm to establish a state-of-the-art federated virtual knowledge graph framework (FVKG) embedded virtualized knowledge graph approach to mitigate the aforementioned challenges effectively. The proposed FVKG helps construct a virtualized data federation leveraging the Ontop semantic query engine that effectively resolves data bottlenecks. Using a virtualized technique, the FVKG helps to reduce data migration, ensures low latency and dynamic freshness, and facilitates real-time access while upholding integrity and coherence throughout the federation system. As a result, we suggest a customized framework for constructing ontological monolithic semantic artifacts, especially in FIS. The proposed FVKG incorporates ontology-based data access (OBDA) to build a monolithic virtualized repository that integrates various ontological-driven artifacts and ensures semantic alignments using schema mapping techniques. © 2025 by the authors.},
keywords = {Data integration, Data interoperability, Federated information systems, Federated ontology, Graph framework, Interoperability, Knowledge graphs, Knowledge management, Medical computing, Ontology, Ontology's, Ontop, Query processing, Semantic interoperability, Semantic Web, Semantics, Virtual knowledge, virtual reality, Virtualization, Virtualized knowledge graph},
pubstate = {published},
tppubtype = {article}
}
Data integration (DI) and semantic interoperability (SI) are critical in healthcare, enabling seamless, patient-centric data sharing across systems to meet the demand for instant, unambiguous access to health information. Federated information systems (FIS) highlight auspicious issues for seamless DI and SI stemming from diverse data sources or models. We present a hybrid ontology-based design science research engineering (ODSRE) methodology that combines design science activities with ontology engineering principles to address the above-mentioned issues. The ODSRE constructs a systematic mechanism leveraging the Ontop virtual paradigm to establish a state-of-the-art federated virtual knowledge graph framework (FVKG) embedded virtualized knowledge graph approach to mitigate the aforementioned challenges effectively. The proposed FVKG helps construct a virtualized data federation leveraging the Ontop semantic query engine that effectively resolves data bottlenecks. Using a virtualized technique, the FVKG helps to reduce data migration, ensures low latency and dynamic freshness, and facilitates real-time access while upholding integrity and coherence throughout the federation system. As a result, we suggest a customized framework for constructing ontological monolithic semantic artifacts, especially in FIS. The proposed FVKG incorporates ontology-based data access (OBDA) to build a monolithic virtualized repository that integrates various ontological-driven artifacts and ensures semantic alignments using schema mapping techniques. © 2025 by the authors.