

de Recherche et d’Innovation
en Cybersécurité et Société
Brideau-Duquette, M.; Côté, S. S. -P.; Boukhalfi, T.; Renaud, P.
Forensic Psychiatry and Big Data: Towards a Cyberphysical System in Service of Clinic, Research and Cybersecurity Article d'actes
Dans: B., Boulay; T., Di Mascio; E., Tovar; C., Meinel (Ed.): International Conference on Computer Supported Education, CSEDU - Proceedings, p. 856–864, Science and Technology Publications, Lda, 2025, ISBN: 21845026 (ISSN); 978-989758746-7 (ISBN), (Journal Abbreviation: International Conference on Computer Supported Education, CSEDU - Proceedings).
Résumé | Liens | BibTeX | Étiquettes: Artificial intelligence, Artificial life, Behavioral research, Computer forensics, Cyber security, Cyber-physical systems, Cyberphysical System, Cybersecurity, Data Lake, Data repositories, Extended Reality, Forensic engineering, Forensic psychiatry, Intelligent computing, prediction, Prevention, Research efforts, Social Engineering, Sociology, System in services
@inproceedings{brideau-duquette_forensic_2025,
title = {Forensic Psychiatry and Big Data: Towards a Cyberphysical System in Service of Clinic, Research and Cybersecurity},
author = {M. Brideau-Duquette and S. S. -P. Côté and T. Boukhalfi and P. Renaud},
editor = {Boulay B. and Di Mascio T. and Tovar E. and Meinel C.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105003621528&doi=10.5220%2f0013496100003932&partnerID=40&md5=ee442c9113f1104973b40ef698bc5d7d},
doi = {10.5220/0013496100003932},
isbn = {21845026 (ISSN); 978-989758746-7 (ISBN)},
year = {2025},
date = {2025-01-01},
booktitle = {International Conference on Computer Supported Education, CSEDU - Proceedings},
volume = {1},
pages = {856–864},
publisher = {Science and Technology Publications, Lda},
abstract = {The advent of big data and artificial intelligence has led to the elaboration of computational psychiatry. In parallel, great progress has been made with extended reality (XR) technologies. In this article, we propose to build a forensic cyberphysical system (CPS) that, with a data lake as its computational and data repository core, will support clinical and research efforts in forensic psychiatry, this in both intramural and extramural settings. The proposed CPS requires offender's data (notably clinical, behavioural and physiological), but also emphasises the collection of such data in various XR contexts. The same data would be used to train machine and deep learning, artificial intelligence, algorithms. Beyond the direct feedback these algorithms could give to forensic specialists, they could help build forensic digital twins. They could also serve in the fine tuning of XR usage with offenders. This paper concludes with human-centered cybersecurity concerns and opportunities the same CPS would imply. The proximity between a forensic and XR-supported CPS and social engineering will be addressed, and special consideration will be given to the opportunity for situational awareness training with offenders. We conclude by sketching ethical and implementation challenges that would require future inquiring. Copyright © 2025 by SCITEPRESS - Science and Technology Publications, Lda.},
note = {Journal Abbreviation: International Conference on Computer Supported Education, CSEDU - Proceedings},
keywords = {Artificial intelligence, Artificial life, Behavioral research, Computer forensics, Cyber security, Cyber-physical systems, Cyberphysical System, Cybersecurity, Data Lake, Data repositories, Extended Reality, Forensic engineering, Forensic psychiatry, Intelligent computing, prediction, Prevention, Research efforts, Social Engineering, Sociology, System in services},
pubstate = {published},
tppubtype = {inproceedings}
}
Brideau-Duquette, M.; Côté, S. S. -P.; Charbonneau, P.; Renaud, P.
When Sexy Avatars Get Weird: How Brain Asymmetry and Oculomotor Dynamics Navigate the Uncanny Article d'actes
Dans: S., Itthipuripat; G.A., Ascoli; A., Li; N., Pat; H., Kuai (Ed.): Lect. Notes Comput. Sci., p. 121–139, Springer Science and Business Media Deutschland GmbH, 2025, ISBN: 03029743 (ISSN); 978-981963293-0 (ISBN), (Journal Abbreviation: Lect. Notes Comput. Sci.).
Résumé | Liens | BibTeX | Étiquettes: Brain, Embodied Computing, Eye-tracking, Gaze behaviours, Human machine interaction, Immersive, Nonlinear index, Psychological effects, regression analysis, Regression modelling, Uncanny, Uncanny valley, Virtual environments, virtual reality
@inproceedings{brideau-duquette_when_2025,
title = {When Sexy Avatars Get Weird: How Brain Asymmetry and Oculomotor Dynamics Navigate the Uncanny},
author = {M. Brideau-Duquette and S. S. -P. Côté and P. Charbonneau and P. Renaud},
editor = {Itthipuripat S. and Ascoli G.A. and Li A. and Pat N. and Kuai H.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105002448490&doi=10.1007%2F978-981-96-3294-7_10&partnerID=40&md5=ced02f5a8061a51f213078ce6d6635f3},
doi = {10.1007/978-981-96-3294-7_10},
isbn = {03029743 (ISSN); 978-981963293-0 (ISBN)},
year = {2025},
date = {2025-01-01},
booktitle = {Lect. Notes Comput. Sci.},
volume = {15541 LNAI},
pages = {121–139},
publisher = {Springer Science and Business Media Deutschland GmbH},
abstract = {This study explores the psychological effects of human-machine interaction, particularly focusing on the phenomenon of the uncanny valley within the context of virtual reality (VR). This study specifically investigates the relationship between oculomotor dynamics, EEG asymmetry, and perceived uncanniness in an immersive setting with a realistic human avatar that can generate uncanny feelings. Participants engaged in a VR scenario designed to optimize their sexual interest. Eye-tracking and EEG data were collected during these interactions to assess the predictors of uncanniness. The final regression model identified significant predictors, including EEG asymmetry in frontal and parietal regions and nonlinear indices of gaze behavior. The findings suggest that the more a participants’ attention was attracted towards specific cues, the higher the uncanniness. The interplay between EEG asymmetries and gaze behavior furthermore indicates that these physiological and behavioral responses are closely linked to the perception of uncanniness, offering insights into how humans interact with increasingly lifelike technologies. These insights contribute to a better understanding of HMI’s potential and may inform the development of more engaging and psychologically attuned virtual content. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.},
note = {Journal Abbreviation: Lect. Notes Comput. Sci.},
keywords = {Brain, Embodied Computing, Eye-tracking, Gaze behaviours, Human machine interaction, Immersive, Nonlinear index, Psychological effects, regression analysis, Regression modelling, Uncanny, Uncanny valley, Virtual environments, virtual reality},
pubstate = {published},
tppubtype = {inproceedings}
}
Horn, J. E. Van; Dongen, J.; Bouman, Y. H. A.; Wallinius, M.; Renaud, P.
Frontiers Media SA, 2024, ISBN: 978-2-8325-5531-6.
@book{van_horn_new_2024,
title = {New Directions in Forensic Psychology: Applying Neuropsychology, Biomarkers and Technology in Assessment & Intervention},
author = {J. E. Van Horn and J. Dongen and Y. H. A. Bouman and M. Wallinius and P. Renaud},
url = {https://books.google.ca/books?id=fNIrEQAAQBAJ},
isbn = {978-2-8325-5531-6},
year = {2024},
date = {2024-01-01},
publisher = {Frontiers Media SA},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
Brideau-Duquette, M.; Côté, S. Saint-Pierre; Charbonneau, P.; Renaud, P.
When Sexy Avatars Get Weird: How Brain Asymmetry and Oculomotor Dynamics Navigate the Uncanny Article d'actes
Dans: Liu, F.; Zhang, Y.; Kuai, H.; Stephen, E. P.; Wang, H. (Ed.): Proceedings of the 17th International Conference on Brain Informatics (BI 2024), p. 1–20, Bangkok, Thailand, 2024.
BibTeX | Étiquettes:
@inproceedings{brideau-duquette_when_2024,
title = {When Sexy Avatars Get Weird: How Brain Asymmetry and Oculomotor Dynamics Navigate the Uncanny},
author = {M. Brideau-Duquette and S. Saint-Pierre Côté and P. Charbonneau and P. Renaud},
editor = {F. Liu and Y. Zhang and H. Kuai and E. P. Stephen and H. Wang},
year = {2024},
date = {2024-01-01},
booktitle = {Proceedings of the 17th International Conference on Brain Informatics (BI 2024)},
pages = {1–20},
address = {Bangkok, Thailand},
keywords = {},
pubstate = {published},
tppubtype = {inproceedings}
}
Côté, S. S. -P.; Brideau-Duquette, M.; Lafortune, D.; Pfaus, J. G.; Renaud, P.
Dans: O., Poquet; A., Ortega-Arranz; O., Viberg; I.-A., Chounta; B., McLaren; J., Jovanovic (Ed.): International Conference on Computer Supported Education, CSEDU - Proceedings, p. 694–700, Science and Technology Publications, Lda, 2024, ISBN: 21845026 (ISSN); 978-989758697-2 (ISBN), (Journal Abbreviation: International Conference on Computer Supported Education, CSEDU - Proceedings).
Résumé | Liens | BibTeX | Étiquettes: Affordances, Behavioral measures, Computer vision, E-learning, Electroencephalography, Electrophysiology, Gaze Behaviour, Gaze behaviours, Immersive, Learning, Physiological measures, Quantitative electroencephalography, Quantitative Electroencephalography (qEEG), Sexual Presence, Therapeutic Application, Vaginal Photoplethysmography, virtual reality
@inproceedings{cote_investigating_2024,
title = {Investigating Female Sexual Presence Through Triangulation of Behavioral and Physiological Measures in Virtual Reality: Towards Therapeutic Applications for Sexual Disorders},
author = {S. S. -P. Côté and M. Brideau-Duquette and D. Lafortune and J. G. Pfaus and P. Renaud},
editor = {Poquet O. and Ortega-Arranz A. and Viberg O. and Chounta I.-A. and McLaren B. and Jovanovic J.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193914916&doi=10.5220%2f0012754700003693&partnerID=40&md5=435ba537cddf1277ed1b459b8a0b1984},
doi = {10.5220/0012754700003693},
isbn = {21845026 (ISSN); 978-989758697-2 (ISBN)},
year = {2024},
date = {2024-01-01},
booktitle = {International Conference on Computer Supported Education, CSEDU - Proceedings},
volume = {1},
pages = {694–700},
publisher = {Science and Technology Publications, Lda},
abstract = {Exposure to sexual contexts by means of immersive, extended reality technologies, offer an opportunity to both: better understand sexual responding, and in turn, offers insights as to how the same technology could help in treating sexual disorders. The present papers reports on the ability of behavioural (i.e., oculometry) and physiological (i.e., electroencephalography and vaginal plethysmography) to conjointly predict subjective sexual feelings (i.e., subjective sexual presence), this, using a sample of 12 heterosexual cisgendered women. Measurements pertained to the participants living a sexual immersion (via a virtual reality headset) with an opposite sex virtual character engaging in sexually suggestive behaviour. Results suggest that all the tested behavioural and physiological measurements could play a role in the shaping of sexual presence. Results are discussed with therapeutic learning processes considerations in mind. Copyright © 2024 by SCITEPRESS – Science and Technology Publications, Lda.},
note = {Journal Abbreviation: International Conference on Computer Supported Education, CSEDU - Proceedings},
keywords = {Affordances, Behavioral measures, Computer vision, E-learning, Electroencephalography, Electrophysiology, Gaze Behaviour, Gaze behaviours, Immersive, Learning, Physiological measures, Quantitative electroencephalography, Quantitative Electroencephalography (qEEG), Sexual Presence, Therapeutic Application, Vaginal Photoplethysmography, virtual reality},
pubstate = {published},
tppubtype = {inproceedings}
}
Côté, S. S. -P.; Brideau-Duquette, M.; Labbé, D.; Renaud, P.
Sexual Presence in Virtual Reality: A qEEG Exploration Article d'actes
Dans: Proc. - IEEE Conf. Virtual Real. 3D User Interfaces Abstr. Workshops, VRW, p. 947–948, Institute of Electrical and Electronics Engineers Inc., 2024, ISBN: 979-835037449-0 (ISBN), (Journal Abbreviation: Proc. - IEEE Conf. Virtual Real. 3D User Interfaces Abstr. Workshops, VRW).
Résumé | Liens | BibTeX | Étiquettes: Electroencephalography, Electrophysiology, Exposed to, Immersive technologies, Quantitative electroencephalography, Sexual Presence, Virtual character, virtual reality, Virtual scenario
@inproceedings{cote_sexual_2024,
title = {Sexual Presence in Virtual Reality: A qEEG Exploration},
author = {S. S. -P. Côté and M. Brideau-Duquette and D. Labbé and P. Renaud},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195564684&doi=10.1109%2fVRW62533.2024.00270&partnerID=40&md5=3b0e533b4b5ab49d00103d5e71792d26},
doi = {10.1109/VRW62533.2024.00270},
isbn = {979-835037449-0 (ISBN)},
year = {2024},
date = {2024-01-01},
booktitle = {Proc. - IEEE Conf. Virtual Real. 3D User Interfaces Abstr. Workshops, VRW},
pages = {947–948},
publisher = {Institute of Electrical and Electronics Engineers Inc.},
abstract = {The increasing use of immersive technologies for sexual purposes raises questions about their capacity to enhance a unique aspect of presence-Sexual Presence (SP). Investigating this phenomenon hinges on our ability to measure it accurately. This paper improves our understanding of SP by identifying potential quantitative electroencephalography variables associated with SP. Twelve heterosexual cisgender males were exposed to virtual scenarios featuring sexual content performed by a Virtual Character (VC). After viewing, participants completed a Sexual Presence questionnaire. Correlations were observed between self-reported SP and the alpha band activity in the frontal and parietal regions. © 2024 IEEE.},
note = {Journal Abbreviation: Proc. - IEEE Conf. Virtual Real. 3D User Interfaces Abstr. Workshops, VRW},
keywords = {Electroencephalography, Electrophysiology, Exposed to, Immersive technologies, Quantitative electroencephalography, Sexual Presence, Virtual character, virtual reality, Virtual scenario},
pubstate = {published},
tppubtype = {inproceedings}
}
Chabot, E.; Jaworski, E.; Renaud, P.
Pervasive Teledildonics: How AI Aims to Impact Human sexuality Article d'actes
Dans: Proc. - IEEE/WIC Int. Conf. Web Intell. Intell. Agent Technol., WI-IAT, p. 898–903, Institute of Electrical and Electronics Engineers Inc., Bangkok, Thailand, 2024, ISBN: 979-833150494-6 (ISBN).
Résumé | Liens | BibTeX | Étiquettes: Ambient intelligence, Anthropomorphic robots, Artificial intelligence, Artificial life, Capability awareness, Computing capability, Context- awareness, Cyber security, Human machine interaction, human-machine interactions, Humans-robot interactions, Industrial robots, Intelligent computing, Intelligent robots, Intelligent systems, Monitoring change, pervasive computing, Robot learning, Sexual satisfaction, sexual technologies, Sexual technology, Social robots, Teledildonic, teledildonics
@inproceedings{chabot_pervasive_2024,
title = {Pervasive Teledildonics: How AI Aims to Impact Human sexuality},
author = {E. Chabot and E. Jaworski and P. Renaud},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105007140928&doi=10.1109%2FWI-IAT62293.2024.00146&partnerID=40&md5=0e1c4d50642661b589db24542641bdf0},
doi = {10.1109/WI-IAT62293.2024.00146},
isbn = {979-833150494-6 (ISBN)},
year = {2024},
date = {2024-01-01},
booktitle = {Proc. - IEEE/WIC Int. Conf. Web Intell. Intell. Agent Technol., WI-IAT},
pages = {898–903},
publisher = {Institute of Electrical and Electronics Engineers Inc.},
address = {Bangkok, Thailand},
abstract = {Since the Covid-19 pandemic, sexual technology sales have increased all over the world, especially for devices allowing users to connect with each other or the internet. The convergence of sexualtechnology with pervasivecomputing and artificial intelligence (AI) introduces a new era of human-robot interactions. Sexual technology, ranging from smart sex toys to humanoid sex robots, now incorporates pervasive computing principles and/or AI to enhance intimate experiences. These devices leverage ubiquitous computing capabilities, adaptability, and context awareness to increase sexual satisfaction and integrate into users' lives. The integration of these technologies into intimate interactions raises questions on how these changes will affect different Webs of Life, in eluding but not limited to, the Web of People, the Web of Things and the Web of Health. From health and cybersecurity risks to the reshaping of human-human and human-robot interactions, this paper addresses the challenges at the intersection of sexual technologies, pervasive computing, AI and human-machine interactions. Emphasizing the importance of monitoring changes and increasing cybersecurity to create safe, consensual, and secure intimate experiences. © 2024 IEEE.},
keywords = {Ambient intelligence, Anthropomorphic robots, Artificial intelligence, Artificial life, Capability awareness, Computing capability, Context- awareness, Cyber security, Human machine interaction, human-machine interactions, Humans-robot interactions, Industrial robots, Intelligent computing, Intelligent robots, Intelligent systems, Monitoring change, pervasive computing, Robot learning, Sexual satisfaction, sexual technologies, Sexual technology, Social robots, Teledildonic, teledildonics},
pubstate = {published},
tppubtype = {inproceedings}
}
Galaup, C.; Séoud, L.; Renaud, P.
Multimodal HCI: A Review of Computational Tools and Their Relevance to the Detection of Sexual Presence Article de journal
Dans: Applied Human Factors and Ergonomics International, vol. 119, p. 137–143, 2024, ISSN: 27710718 (ISSN).
Résumé | Liens | BibTeX | Étiquettes: EEG analysis, Multimodal HCI, Physiological signal analysis
@article{galaup_multimodal_2024,
title = {Multimodal HCI: A Review of Computational Tools and Their Relevance to the Detection of Sexual Presence},
author = {C. Galaup and L. Séoud and P. Renaud},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105031152209&doi=10.54941%2Fahfe1004477&partnerID=40&md5=90b218deab22b451986584c149aab11c},
doi = {10.54941/ahfe1004477},
issn = {27710718 (ISSN)},
year = {2024},
date = {2024-01-01},
journal = {Applied Human Factors and Ergonomics International},
volume = {119},
pages = {137–143},
abstract = {Cybersexuality, referring to sexual interactions facilitated by or involving sexual technologies, for better or worse, is poised to play an increasingly significant role in people’s lives. The psychophysiological states stemming from such interactions with sexual technologies, and especially virtual reality (VR) scenarios, is termed “sexual presence” (SP). This work aims to review the different methods used to analyse and algorithmically evaluate multimodal electroencephalography (EEG)-centric physiological signals through a multimodal human-computer interface (HCI) and to pinpoint those who prove relevant to the detection of SP. Multimodal HCI are defined as the processing of combined natural modalities with multimedia system or environment. Each modality engages different human capabilities (cognitive, sensory, motion, perceptual). These capabilities, in response to the multimedia environment, can be quantified through psychophysiological signals such as EEG, electrocardiography (ECG), skin conductance, skin temperature, respiration rate, eye gaze, head movements, to name only the most common. While existing surveys have focused on the specific use of EEG to analyse emotions or on the measurement techniques and methods that have been used to record psycho-physiological signals, this work reviews the computational tools, mostly using machine and deep learning, to process, analyse and combine various physiological signals in HCI. Papers published in the last 10 years, combining at least two psycho-physiological signals in an HCI system were collected and reviewed, regardless of the field of application. The focus was mostly on the methodological aspects such as signal synchronization and calibration, fusion approach, model architecture, learning strategy. We put an emphasis on the methods that can be used to detect a subject’s condition in real time. At the light of this review, we can identify a research gap in terms of computational tools for multimodal data classification and prediction. This review will allow us to draw on existing work in other fields of application to address our specific application: to analyse EEG, oculometry and sexual plethysmography (penile for the men and vaginal for the women) signals together, using deep learning, to detect SP in subject immersed in an VR environment presenting sexual content. © 2024. Published by AHFE Open Access. All rights reserved.},
keywords = {EEG analysis, Multimodal HCI, Physiological signal analysis},
pubstate = {published},
tppubtype = {article}
}
Brideau-Duquette, M.; Côté, S. S. -P.; Pfaus, J. G.; Renaud, P.
First Cross-Entropy Associated With Virtual Sexual Content Article de journal
Dans: Applied Human Factors and Ergonomics International, vol. 119, p. 110–119, 2024, ISSN: 27710718 (ISSN).
Résumé | Liens | BibTeX | Étiquettes: Brain entropy, Electroencephalography, eye tracking, immersion, Sexual Presence, virtual reality
@article{brideau-duquette_first_2024,
title = {First Cross-Entropy Associated With Virtual Sexual Content},
author = {M. Brideau-Duquette and S. S. -P. Côté and J. G. Pfaus and P. Renaud},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105031273879&doi=10.54941%2Fahfe1004474&partnerID=40&md5=3a1b6f10201659be05b3feebea9c6dfd},
doi = {10.54941/ahfe1004474},
issn = {27710718 (ISSN)},
year = {2024},
date = {2024-01-01},
journal = {Applied Human Factors and Ergonomics International},
volume = {119},
pages = {110–119},
abstract = {This study investigates the brain’s response to virtual sexual content using EEG dynamic cross-entropy and physiological measures of arousal. It aims to elucidate the neural underpinnings of “sexual presence”—a state of arousal influenced by personal predispositions and technological affordances. The research integrates concepts of sexual affordances within embodied cognitive processes, suggesting that the brain optimizes responses to minimize free energy when processing sexual cues. The findings show that sexual avatars trigger specific arousal and attention, evidenced by physiological arousal responses. Notably, frontal cross-entropy in the low alpha band decreased during exposure to sexual content, suggesting a more streamlined frontal information transfer during arousal. The results contribute to understanding how virtual environments can induce sexual presence, indicating that sexual affordances in virtual settings significantly influence cognitive engagement and neural efficiency. The study’s outcomes have implications in the understanding of human-machine interactions with virtual content mobilizing sexual cognition. © 2024. Published by AHFE.},
keywords = {Brain entropy, Electroencephalography, eye tracking, immersion, Sexual Presence, virtual reality},
pubstate = {published},
tppubtype = {article}
}
Doney, E.; Dion-Albert, L.; Coulombe-Rozon, F.; Osborne, N.; Bernatchez, R.; Paton, S. E. J.; Kaufmann, F. N.; Agomma, R. O.; Solano, J. L.; Gaumond, R.; Dudek, K. A.; Szyszkowicz, J. K.; Aardema, F.; Bentaleb, L. A.; Beauchamp, J.; Bendahmane, H.; Benoit, E.; Bergeron, L.; Bertone, A.; Bertrand, N.; Berube, F. -A.; Blanchet, P.; Boissonneault, J.; Bolduc, C. J.; Bonin, J. -P.; Borgeat, F.; Boyer, R.; Breault, C.; Breton, J. -J.; Briand, C.; Brodeur, J.; Brule, K.; Brunet, L.; Carriere, S.; Chartrand, C.; Chenard-Soucy, R.; Chevrette, T.; Cloutier, E.; Cloutier, R.; Cormier, H.; Cote, G.; Cyr, J.; David, P.; Benedictis, L. De; Delisle, M. -C.; Deschenes, P.; Desjardins, C. D.; Desmarais, G.; Dubreucq, J. -L.; Dumont, M.; Dumais, A.; Ethier, G.; Feltrin, C.; Felx, A.; Findlay, H.; Fortier, L.; Fortin, D.; Fortin, L.; Francois, N.; Gagne, V.; Gagnon, M. -P.; Gignac-Hens, M. -C.; Giguere, C. -E.; Godbout, R.; Grou, C.; Guay, S.; Guillem, F.; Hachimi-Idrissi, N.; Herry, C.; Hodgins, S.; Homayoun, S.; Jemel, B.; Joyal, C.; Kouassi, E.; Labelle, R.; Lafortune, D.; Lahaie, M.; Lahlafi, S.; Lalonde, P.; Landry, P.; Lapaige, V.; Larocque, G.; Larue, C.; Lavoie, M.; Leclerc, J. -J.; Lecomte, T.; Lecours, C.; Leduc, L.; Lelan, M. -F.; Lemieux, A.; Lesage, A.; Letarte, A.; Lepage, J.; Levesque, A.; Lipp, O.; Luck, D.; Lupien, S.; Lusignan, F. -A.; Lusignan, R.; Luyet, A. J.; Lynhiavu, A.; Melun, J. -P.; Morin, C.; Nicole, L.; Noel, F.; Normandeau, L.; O'Connor, K.; Ouellette, C.; Parent, V.; Parizeau, M. -H.; Pelletier, J. -F.; Pelletier, J.; Pelletier, M.; Plusquellec, P.; Poirier, D.; Potvin, S.; Prevost, G.; Prevost, M. -J.; Racicot, P.; Racine-Gagne, M. -F.; Renaud, P.; Ricard, N.; Rivet, S.; Rolland, M.; Sasseville, M.; Safadi, G.; Smith, S.; Smolla, N.; Stip, E.; Teitelbaum, J.; Thibault, A.; Thibault, L.; Thibault, S.; Thomas, F.; Todorov, C.; Tourjman, V.; Tranulis, C.; Trudeau, S.; Trudel, G.; Vacri, N.; Valiquette, L.; Vanier, C.; Villeneuve, K.; Villeneuve, M.; Vincent, P.; Wolfe, M.; Xiong, L.; Zizzi, A.; Lebel, M.; Doyen, A.; Durand, A.; Lavoie-Cardinal, F.; Audet, M. -C.; Menard, C.; on behalf of Signature Consortium, Cecile Lepage
Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions Article de journal
Dans: Biological Psychiatry Global Open Science, vol. 4, no 1, p. 213–228, 2024, ISSN: 26671743 (ISSN), (Publisher: Elsevier Inc.).
Résumé | Liens | BibTeX | Étiquettes: animal experiment, animal model, animal tissue, article, chronic social defeat, chronic stress, chronic variable stress, claudin 3, Claudins, controlled study, corticosterone, corticosterone blood level, Cytokines, enzyme linked immunosorbent assay, female, human, immunohistochemistry, intestine flora, jejunum, lipopolysaccharide, lipopolysaccharide binding protein, Machine learning, major depression, male, mouse, nonhuman, pathogenesis, protein expression, real time polymerase chain reaction, sex difference, sex differences, social stress, tight junction, Variable stress
@article{doney_chronic_2024,
title = {Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions},
author = {E. Doney and L. Dion-Albert and F. Coulombe-Rozon and N. Osborne and R. Bernatchez and S. E. J. Paton and F. N. Kaufmann and R. O. Agomma and J. L. Solano and R. Gaumond and K. A. Dudek and J. K. Szyszkowicz and F. Aardema and L. A. Bentaleb and J. Beauchamp and H. Bendahmane and E. Benoit and L. Bergeron and A. Bertone and N. Bertrand and F. -A. Berube and P. Blanchet and J. Boissonneault and C. J. Bolduc and J. -P. Bonin and F. Borgeat and R. Boyer and C. Breault and J. -J. Breton and C. Briand and J. Brodeur and K. Brule and L. Brunet and S. Carriere and C. Chartrand and R. Chenard-Soucy and T. Chevrette and E. Cloutier and R. Cloutier and H. Cormier and G. Cote and J. Cyr and P. David and L. De Benedictis and M. -C. Delisle and P. Deschenes and C. D. Desjardins and G. Desmarais and J. -L. Dubreucq and M. Dumont and A. Dumais and G. Ethier and C. Feltrin and A. Felx and H. Findlay and L. Fortier and D. Fortin and L. Fortin and N. Francois and V. Gagne and M. -P. Gagnon and M. -C. Gignac-Hens and C. -E. Giguere and R. Godbout and C. Grou and S. Guay and F. Guillem and N. Hachimi-Idrissi and C. Herry and S. Hodgins and S. Homayoun and B. Jemel and C. Joyal and E. Kouassi and R. Labelle and D. Lafortune and M. Lahaie and S. Lahlafi and P. Lalonde and P. Landry and V. Lapaige and G. Larocque and C. Larue and M. Lavoie and J. -J. Leclerc and T. Lecomte and C. Lecours and L. Leduc and M. -F. Lelan and A. Lemieux and A. Lesage and A. Letarte and J. Lepage and A. Levesque and O. Lipp and D. Luck and S. Lupien and F. -A. Lusignan and R. Lusignan and A. J. Luyet and A. Lynhiavu and J. -P. Melun and C. Morin and L. Nicole and F. Noel and L. Normandeau and K. O'Connor and C. Ouellette and V. Parent and M. -H. Parizeau and J. -F. Pelletier and J. Pelletier and M. Pelletier and P. Plusquellec and D. Poirier and S. Potvin and G. Prevost and M. -J. Prevost and P. Racicot and M. -F. Racine-Gagne and P. Renaud and N. Ricard and S. Rivet and M. Rolland and M. Sasseville and G. Safadi and S. Smith and N. Smolla and E. Stip and J. Teitelbaum and A. Thibault and L. Thibault and S. Thibault and F. Thomas and C. Todorov and V. Tourjman and C. Tranulis and S. Trudeau and G. Trudel and N. Vacri and L. Valiquette and C. Vanier and K. Villeneuve and M. Villeneuve and P. Vincent and M. Wolfe and L. Xiong and A. Zizzi and M. Lebel and A. Doyen and A. Durand and F. Lavoie-Cardinal and M. -C. Audet and C. Menard and Cecile Lepage on behalf of Signature Consortium},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162172419&doi=10.1016%2fj.bpsgos.2023.04.007&partnerID=40&md5=aae4250eee5bd708599126cf76c3f5d7},
doi = {10.1016/j.bpsgos.2023.04.007},
issn = {26671743 (ISSN)},
year = {2024},
date = {2024-01-01},
journal = {Biological Psychiatry Global Open Science},
volume = {4},
number = {1},
pages = {213–228},
publisher = {Elsevier Inc.},
abstract = {Background: Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain barrier integrity; still, little is known about intestinal barrier function in these conditions, particularly for the small intestine, where absorption of most foods and drugs takes place. Methods: We investigated how chronic social or variable stress, two mouse models of depression, impact the jejunum intestinal barrier in males and females. Mice were subjected to stress paradigms followed by analysis of gene expression profiles of intestinal barrier–related targets, fecal microbial composition, and blood-based markers. Results: Altered microbial populations and changes in gene expression of jejunum tight junctions were observed depending on the type and duration of stress, with sex-specific effects. We used machine learning to characterize in detail morphological tight junction properties, identifying a cluster of ruffled junctions in stressed animals. Junctional ruffling is associated with inflammation, so we evaluated whether lipopolysaccharide injection recapitulates stress-induced changes in the jejunum and observed profound sex differences. Finally, lipopolysaccharide-binding protein, a marker of gut barrier leakiness, was associated with stress vulnerability in mice, and translational value was confirmed on blood samples from women with MDD. Conclusions: Our results provide evidence that chronic stress disrupts intestinal barrier homeostasis in conjunction with the manifestation of depressive-like behaviors in a sex-specific manner in mice and, possibly, in human depression. © 2023 The Authors},
note = {Publisher: Elsevier Inc.},
keywords = {animal experiment, animal model, animal tissue, article, chronic social defeat, chronic stress, chronic variable stress, claudin 3, Claudins, controlled study, corticosterone, corticosterone blood level, Cytokines, enzyme linked immunosorbent assay, female, human, immunohistochemistry, intestine flora, jejunum, lipopolysaccharide, lipopolysaccharide binding protein, Machine learning, major depression, male, mouse, nonhuman, pathogenesis, protein expression, real time polymerase chain reaction, sex difference, sex differences, social stress, tight junction, Variable stress},
pubstate = {published},
tppubtype = {article}
}



