@article{doney_chronic_2024,

title = {Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions},

author = {E. Doney and L. Dion-Albert and F. Coulombe-Rozon and N. Osborne and R. Bernatchez and S. E. J. Paton and F. N. Kaufmann and R. O. Agomma and J. L. Solano and R. Gaumond and K. A. Dudek and J. K. Szyszkowicz and F. Aardema and L. A. Bentaleb and J. Beauchamp and H. Bendahmane and E. Benoit and L. Bergeron and A. Bertone and N. Bertrand and F. -A. Berube and P. Blanchet and J. Boissonneault and C. J. Bolduc and J. -P. Bonin and F. Borgeat and R. Boyer and C. Breault and J. -J. Breton and C. Briand and J. Brodeur and K. Brule and L. Brunet and S. Carriere and C. Chartrand and R. Chenard-Soucy and T. Chevrette and E. Cloutier and R. Cloutier and H. Cormier and G. Cote and J. Cyr and P. David and L. De Benedictis and M. -C. Delisle and P. Deschenes and C. D. Desjardins and G. Desmarais and J. -L. Dubreucq and M. Dumont and A. Dumais and G. Ethier and C. Feltrin and A. Felx and H. Findlay and L. Fortier and D. Fortin and L. Fortin and N. Francois and V. Gagne and M. -P. Gagnon and M. -C. Gignac-Hens and C. -E. Giguere and R. Godbout and C. Grou and S. Guay and F. Guillem and N. Hachimi-Idrissi and C. Herry and S. Hodgins and S. Homayoun and B. Jemel and C. Joyal and E. Kouassi and R. Labelle and D. Lafortune and M. Lahaie and S. Lahlafi and P. Lalonde and P. Landry and V. Lapaige and G. Larocque and C. Larue and M. Lavoie and J. -J. Leclerc and T. Lecomte and C. Lecours and L. Leduc and M. -F. Lelan and A. Lemieux and A. Lesage and A. Letarte and J. Lepage and A. Levesque and O. Lipp and D. Luck and S. Lupien and F. -A. Lusignan and R. Lusignan and A. J. Luyet and A. Lynhiavu and J. -P. Melun and C. Morin and L. Nicole and F. Noel and L. Normandeau and K. O'Connor and C. Ouellette and V. Parent and M. -H. Parizeau and J. -F. Pelletier and J. Pelletier and M. Pelletier and P. Plusquellec and D. Poirier and S. Potvin and G. Prevost and M. -J. Prevost and P. Racicot and M. -F. Racine-Gagne and P. Renaud and N. Ricard and S. Rivet and M. Rolland and M. Sasseville and G. Safadi and S. Smith and N. Smolla and E. Stip and J. Teitelbaum and A. Thibault and L. Thibault and S. Thibault and F. Thomas and C. Todorov and V. Tourjman and C. Tranulis and S. Trudeau and G. Trudel and N. Vacri and L. Valiquette and C. Vanier and K. Villeneuve and M. Villeneuve and P. Vincent and M. Wolfe and L. Xiong and A. Zizzi and M. Lebel and A. Doyen and A. Durand and F. Lavoie-Cardinal and M. -C. Audet and C. Menard and Cecile Lepage on behalf of Signature Consortium},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162172419&doi=10.1016%2fj.bpsgos.2023.04.007&partnerID=40&md5=aae4250eee5bd708599126cf76c3f5d7},

doi = {10.1016/j.bpsgos.2023.04.007},

issn = {26671743 (ISSN)},

year  = {2024},

date = {2024-01-01},

journal = {Biological Psychiatry Global Open Science},

volume = {4},

number = {1},

pages = {213–228},

abstract = {Background: Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain barrier integrity; still, little is known about intestinal barrier function in these conditions, particularly for the small intestine, where absorption of most foods and drugs takes place. Methods: We investigated how chronic social or variable stress, two mouse models of depression, impact the jejunum intestinal barrier in males and females. Mice were subjected to stress paradigms followed by analysis of gene expression profiles of intestinal barrier–related targets, fecal microbial composition, and blood-based markers. Results: Altered microbial populations and changes in gene expression of jejunum tight junctions were observed depending on the type and duration of stress, with sex-specific effects. We used machine learning to characterize in detail morphological tight junction properties, identifying a cluster of ruffled junctions in stressed animals. Junctional ruffling is associated with inflammation, so we evaluated whether lipopolysaccharide injection recapitulates stress-induced changes in the jejunum and observed profound sex differences. Finally, lipopolysaccharide-binding protein, a marker of gut barrier leakiness, was associated with stress vulnerability in mice, and translational value was confirmed on blood samples from women with MDD. Conclusions: Our results provide evidence that chronic stress disrupts intestinal barrier homeostasis in conjunction with the manifestation of depressive-like behaviors in a sex-specific manner in mice and, possibly, in human depression. © 2023 The Authors},

note = {Publisher: Elsevier Inc.},

keywords = {animal experiment, animal model, animal tissue, article, chronic social defeat, chronic stress, chronic variable stress, claudin 3, Claudins, controlled study, corticosterone, corticosterone blood level, Cytokines, enzyme linked immunosorbent assay, female, human, immunohistochemistry, intestine flora, jejunum, lipopolysaccharide, lipopolysaccharide binding protein, Machine learning, major depression, male, mouse, nonhuman, pathogenesis, protein expression, real time polymerase chain reaction, sex difference, sex differences, social stress, tight junction, Variable stress},

pubstate = {published},

tppubtype = {article}

}

@article{gabriel_self-report_2024,

title = {Self-report psychopathy-III facet scores predict sexual crimes, sexual preferences, and sexual deviance index validity more precisely than total scores},

author = {S. A. Gabriel and P. Renaud},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190127294&doi=10.3389%2ffpsyg.2024.1359720&partnerID=40&md5=7e60d26cff4a7a888517a15b65e90310},

doi = {10.3389/fpsyg.2024.1359720},

issn = {16641078},

year  = {2024},

date = {2024-01-01},

journal = {Frontiers in Psychology},

volume = {15},

abstract = {Understanding the profiles of sexual offenders, such as the presence of psychopathic traits, is key to preventing future sexual crimes. The self-report psychopathy-III (SRP-III) is a tool used to assess the characteristics of psychopathy, but improvements on its interpretation are required to maximize its precision. The SRP-III can be interpreted by examining the scores on each of the four facets (interpersonal manipulation, callous affect, erratic lifestyle, antisocial behavior), on each of two factors (factor 1, factor 2), or by examining the total score. Here, we investigate the interpretation of the results from the SRP-III using these three approaches of analysis of the data for predicting types of sexual crimes, sexually deviant preferences (measured via PPG), and the validity of the sexual deviance results. Logistic regressions were carried out using either the four facets, two factors, or the total score of the SRP-III. Data were previously obtained from 198 Canadian men who were convicted of, or who admitted to committing, at least one sexual crime, or who reported experiencing sexually deviant fantasies. We also examined the point-biserial correlations between each of the methods of interpreting the SRP-III results and each of the dependent variables. We find that SRP-III facet scores most precisely predict types of sexual crimes, sexually deviant preferences, and sexual deviance index validity, followed by SRP-III factor scores, and lastly SRP-III total scores. Additionally, significant correlations are only found between SRP-III scores and one dependent variable. Potential reasons for this are discussed. Based on these findings, we recommend that future studies consider facet and factor scores in addition to the standard practice of examining total scores. Copyright © 2024 Gabriel and Renaud.},

note = {Publisher: Frontiers Media SA},

keywords = {psychopathy, self-report psychopathy-III, sexual crimes, sexual deviance index validity, sexual preference},

pubstate = {published},

tppubtype = {article}

}

@article{maneuvrier_predicting_2023,

title = {Predicting VR cybersickness and its impact on visuomotor performance using head rotations and field (in)dependence},

author = {A. Maneuvrier and N. -D. -T. Nguyen and P. Renaud},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179320726&doi=10.3389%2ffrvir.2023.1307925&partnerID=40&md5=4adc7d887e2cc90e791e4c19c0bb741d},

doi = {10.3389/frvir.2023.1307925},

issn = {26734192},

year  = {2023},

date = {2023-01-01},

journal = {Frontiers in Virtual Reality},

volume = {4},

abstract = {Introduction: This exploratory study aims to participate in the development of the VR framework by focusing on the issue of cybersickness. The main objective is to explore the possibilities of predicting cybersickness using i) field dependence-independence measures and ii) head rotations data through automatic analyses. The second objective is to assess the impact of cybersickness on visuomotor performance. Methods: 40 participants completed a 13.5-min VR immersion in a first-person shooter game. Head rotations were analyzed in both their spatial (coefficients of variations) and temporal dimensions (detrended fluctuations analyses). Exploratory correlations, linear regressions and clusters comparison (unsupervised machine learning) analyses were performed to explain cybersickness and visuomotor performance. Traditional VR human factors (sense of presence, state of flow, video game experience, age) were also integrated. Results: Results suggest that field dependence-independence measured before exposure to VR explain ¼ of the variance of cybersickness, while the Disorientation scale of the Simulator Sickness Questionnaire predicts 16.3% of the visuomotor performance. In addition, automatic analyses of head rotations during immersion revealed two different clusters of participants, one of them reporting more cybersickness than the other. Discussion: These results are discussed in terms of sensory integration and a diminution of head rotations as an avoidance behavior of negative symptoms. This study suggests that measuring field dependence-independence using the (Virtual) Rod and Frame Test before immersion and tracking head rotations using internal sensors during immersion might serve as powerful tools for VR actors. Copyright © 2023 Maneuvrier, Nguyen and Renaud.},

note = {Publisher: Frontiers Media SA},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{maneuvrier_virtual_2023,

title = {Virtual reality and neuropsychological assessment: an analysis of human factors influencing performance and perceived mental effort},

author = {A. Maneuvrier and H. Ceyte and P. Renaud and R. Morello and P. Fleury and L. M. Decker},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138552678&doi=10.1007%2fs10055-022-00698-4&partnerID=40&md5=631390bbdefb4b05de9565fb986e1923},

doi = {10.1007/s10055-022-00698-4},

issn = {13594338},

year  = {2023},

date = {2023-01-01},

journal = {Virtual Reality},

volume = {27},

number = {2},

pages = {849–861},

abstract = {This study aimed to compare a neuropsychological test tapping into executive control function, the Wisconsin Card Sorting Test (WCST), performed in either traditional paper-and-pencil (PP) or virtual reality (VR) modality, and to determine the role of human factors (i.e., sense of presence, cybersickness, field (in)dependence and video game experience) as contributors to performance and perceived mental effort. Indeed, if virtual assessment might bring the ecological dimension to controlled laboratory research, it is often suggested that human factors might bias performance. WCST performance and its associated perceived mental effort were compared between the two modalities (N = 107). In the VR modality (N = 52), a correlation matrix was conducted as well as a cluster analysis in order to build two experimental groups, or profiles, based on their subjective experience of VR. WCST performance and perceived mental effort were then compared between these two groups while controlling for age and education. Results outlined a similar WCST performance and perceived mental effort between the PP and VR modalities. However, when comparing the two VR groups, results suggest that an unfavorable profile for VR, i.e., less sense of presence, more cybersickness, more visual field dependence and less video game experience, is associated with greater perceived mental effort. These experimental findings enable outlining a new conceptual and methodological framework for the assessment of executive control task performance in VR. Results could help users to take human factors into consideration in order to fully exploit or predict the benefits of this tool. © 2022, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.},

note = {Publisher: Springer Science and Business Media Deutschland GmbH},

keywords = {Cluster Analysis, cybersickness, Executive control of attention, Field dependence, Field dependence–independence, Game experience, Human computer interaction, Human engineering, Interactive computer graphics, Mental effort, Sense of presences, Video game experience, Video-games, virtual reality, WISCONSIN},

pubstate = {published},

tppubtype = {article}

}

@article{dion-albert_vascular_2022,

title = {Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue},

author = {L. Dion-Albert and A. Cadoret and E. Doney and F. N. Kaufmann and K. A. Dudek and B. Daigle and L. F. Parise and F. Cathomas and N. Samba and N. Hudson and M. Lebel and F. Aardema and L. Ait Bentaleb and J. Beauchamp and H. Bendahmane and E. Benoit and L. Bergeron and A. Bertone and N. Bertrand and F. -A. Berube and P. Blanchet and J. Boissonneault and C. J. Bolduc and J. -P. Bonin and F. Borgeat and R. Boyer and C. Breault and J. -J. Breton and C. Briand and J. Brodeur and K. Brule and L. Brunet and S. Carriere and C. Chartrand and R. Chenard-Soucy and T. Chevrette and E. Cloutier and R. Cloutier and H. Cormier and G. Cote and J. Cyr and P. David and L. De Benedictis and M. -C. Delisle and P. Deschenes and C. D. Desjardins and G. Desmarais and J. -L. Dubreucq and M. Dumont and A. Dumais and G. Ethier and C. Feltrin and A. Felx and H. Findlay and L. Fortier and D. Fortin and L. Fortin and N. Francois and V. Gagne and M. -P. Gagnon and M. -C. Gignac-Hens and C. -E. Giguere and R. Godbout and C. Grou and S. Guay and F. Guillem and N. Hachimi-Idrissi and C. Herry and S. Hodgins and S. Homayoun and B. Jemel and C. Joyal and E. Kouassi and R. Labelle and D. Lafortune and M. Lahaie and S. Lahlafi and P. Lalonde and P. Landry and V. Lapaige and G. Larocque and C. Larue and M. Lavoie and J. -J. Leclerc and T. Lecomte and C. Lecours and L. Leduc and M. -F. Lelan and A. Lemieux and A. Lesage and A. Letarte and J. Lepage and A. Levesque and O. Lipp and D. Luck and S. Lupien and F. -A. Lusignan and R. Lusignan and A. J. Luyet and A. Lynhiavu and J. -P. Melun and C. Morin and L. Nicole and F. Noel and L. Normandeau and K. O’Connor and C. Ouellette and V. Parent and M. -H. Parizeau and J. -F. Pelletier and J. Pelletier and M. Pelletier and P. Plusquellec and D. Poirier and S. Potvin and G. Prevost and M. -J. Prevost and P. Racicot and M. -F. Racine-Gagne and P. Renaud and N. Ricard and S. Rivet and M. Rolland and M. Sasseville and G. Safadi and S. Smith and N. Smolla and E. Stip and J. Teitelbaum and A. Thibault and L. Thibault and S. Thibault and F. Thomas and C. Todorov and V. Tourjman and C. Tranulis and S. Trudeau and G. Trudel and N. Vacri and L. Valiquette and C. Vanier and K. Villeneuve and M. Villeneuve and P. Vincent and M. Wolfe and L. Xiong and A. Zizzi and M. Campbell and G. Turecki and N. Mechawar and C. Menard and Signature Consortium},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122874135&doi=10.1038%2fs41467-021-27604-x&partnerID=40&md5=adb636347db6326c701651295e2bb7e1},

doi = {10.1038/s41467-021-27604-x},

issn = {20411723},

year  = {2022},

date = {2022-01-01},

journal = {Nature Communications},

volume = {13},

number = {1},

abstract = {Prevalence, symptoms, and treatment of depression suggest that major depressive disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is associated with depressive symptoms in male mice; however, this association is unclear in females. Here, we report that chronic social and subchronic variable stress promotes blood-brain barrier (BBB) alterations in mood-related brain regions of female mice. Targeted disruption of the BBB in the female prefrontal cortex (PFC) induces anxiety- and depression-like behaviours. By comparing the endothelium cell-specific transcriptomic profiling of the mouse male and female PFC, we identify several pathways and genes involved in maladaptive stress responses and resilience to stress. Furthermore, we confirm that the BBB in the PFC of stressed female mice is leaky. Then, we identify circulating vascular biomarkers of chronic stress, such as soluble E-selectin. Similar changes in circulating soluble E-selectin, BBB gene expression and morphology can be found in blood serum and postmortem brain samples from women diagnosed with MDD. Altogether, we propose that BBB dysfunction plays an important role in modulating stress responses in female mice and possibly MDD. © 2022, The Author(s).},

note = {Publisher: Nature Research},

keywords = {animal, animal experiment, animal model, animal tissue, Animals, Anxiety, article, biological marker, Biological Transport, Biomarkers, blood brain barrier, blood sampling, blood system disorder, Blood-Brain Barrier, brain region, claudin 5, controlled study, Depression, Depressive Disorder, down regulation, doxycycline, E-Selectin, elevated plus maze test, Endothelial Cells, endothelial leukocyte adhesion molecule 1, endothelium cell, enzyme linked immunosorbent assay, estrus cycle, experimental test, female, flow cytometry, forced swim test, gene expression, Gene Expression Profiling, gene transfer, genetics, human, human cell, human tissue, Humans, immunohistochemistry, immunophenotyping, ketamine, Major, major depression, male, Mental health, mental stress, metabolism, Mice, mouse, nerve protein, Nerve Tissue Proteins, nonhuman, Nucleus Accumbens, oxidative stress, pathology, Prefrontal Cortex, Prevalence, Psychological, psychological resilience, quality control, RNA extraction, RNA isolation, RNA sequence, rodent, Sex Characteristics, sexual characteristics, social avoidance, social interaction, social stress, splash test, Stress, stress assessment, sucrose preference test, Transcriptome, transport at the cellular level, urinalysis, urine sampling, vascularization, xylene},

pubstate = {published},

tppubtype = {article}

}

@article{maneuvrier_field_2021,

title = {Field (In)dependence Flexibility Following a Virtual Immersion Is Associated With Cybersickness and Sense of Presence},

author = {A. Maneuvrier and L. M. Decker and P. Renaud and G. Ceyte and H. Ceyte},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138074685&doi=10.3389%2ffrvir.2021.706712&partnerID=40&md5=f6e990593acce7bfaa65de6c03cc3cb5},

doi = {10.3389/frvir.2021.706712},

issn = {26734192},

year  = {2021},

date = {2021-01-01},

journal = {Frontiers in Virtual Reality},

volume = {2},

abstract = {Field dependence–independence (FDI) is a psychological construct determining an individual’s approach of the perception–cognition coupling. In virtual reality (VR) context, several studies suggest that an individual’s perceptive style is susceptible to shift toward a more FI mode through down-weighting of conflicting visual cues. The present study proposes to investigate the potential flexible nature of FDI following a virtual immersion and to assess if this flexibility might be associated with the subjective experience of VR. 86 participants explored a real-world–like virtual environment for approximately 10 min. FDI levels were measured before and after the VR exposure using the rod-and-frame test. Their subjective experience of VR was measured a posteriori (cybersickness and sense of presence) and used in order to build two experimental groups via a cluster analysis. The results showed that only participants with a poor subjective experience of VR (i.e., a low level of sense of presence associated with a high level of cybersickness) significantly shifted to a more FI mode, which is discussed as a sensory re-weighting mechanism. Pragmatical applications are discussed, and future studies are outlined, based on the conclusion that FDI might be more flexible than we thought, which could shed light on the psychophysiology of VR. Copyright © 2021 Maneuvrier, Decker, Renaud, Ceyte and Ceyte.},

note = {Publisher: Frontiers Media S.A.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{bouchard_arguing_2021,

title = {Arguing in Favor of Revising the Simulator Sickness Questionnaire Factor Structure When Assessing Side Effects Induced by Immersions in Virtual Reality},

author = {S. Bouchard and M. Berthiaume and G. Robillard and H. Forget and C. Daudelin-Peltier and P. Renaud and C. Blais and D. Fiset},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119514106&doi=10.3389%2ffpsyt.2021.739742&partnerID=40&md5=83c5198937636133854ac31ad7f749a5},

doi = {10.3389/fpsyt.2021.739742},

issn = {16640640 (ISSN)},

year  = {2021},

date = {2021-01-01},

journal = {Frontiers in Psychiatry},

volume = {12},

abstract = {Two issues are increasingly of interest in the scientific literature regarding unwanted virtual reality (VR) induced side effects: (1) whether the latent structure of the Simulator Sickness Questionnaire (SSQ) is comprised of two or three factors, and (2) if the SSQ measures symptoms of anxiety that can be misattributed to unwanted negative side effects induced by immersions in VR. Study 1 was conducted with a sample of 876 participants. A confirmatory factor analysis clearly supported a two-factor model composed of nausea and oculomotor symptoms instead of the 3-factor structure observed in simulators. To tease-out symptoms of anxiety from unwanted negative side effects induced by immersions in VR, Study 2 was conducted with 88 participants who were administered the Trier Stress Social Test in groups without being immersed in VR. A Spearman correlation showed that 11 out of 16 side effects correlated significantly with anxiety. A factor analysis revealed that items measuring general discomfort, difficulty concentrating, sweating, nausea, and vertigo loaded significantly on the anxiety factor comprised of items from the State-Trait Anxiety Inventory. Finally, a multiple regression indicated that the items measuring general discomfort and difficulty concentrating significantly predicted increases in anxiety. The overall results support the notion that side effects associated with immersions in VR consist mostly of a nausea and an oculomotor latent structure and that a few items are confounding anxiety and cybersickness. The data support the suggestion to revise the scoring procedures of the Simulator Sickness Questionnaire when using this instrument with immersions in VR. Copyright © 2021 Bouchard, Berthiaume, Robillard, Forget, Daudelin-Peltier, Renaud, Blais and Fiset.},

note = {Publisher: Frontiers Media S.A.},

keywords = {adult, Anxiety, Anxiety disorder, article, attention disturbance, blurred vision, confounding variable, controlled study, correlational study, cybersickness, disease association, dizziness, eye movement disorder, fatigue, female, headache, human, hypersalivation, immersion, major clinical study, male, nausea, scoring system, simulator sickness, Simulator Sickness Questionnaire, State Trait Anxiety Inventory, stomach disease, sweat gland disease, sweating, Trier Stress Social Test, vertigo, virtual reality},

pubstate = {published},

tppubtype = {article}

}