Slide
Centre Interdisciplinaire
de Recherche et d’Innovation
en Cybersécurité et Société
de Recherche et d’Innovation
en Cybersécurité et Société
1.
Du, K. Le; Septans, A. -L.; Maloisel, F.; Vanquaethem, H.; Schmitt, A.; Goff, M. Le; Clavert, A.; Zinger, M.; Bourgeois, H.; Dupuis, O.; Denis, F.; Bouchard, S.
A New Option for Pain Prevention Using a Therapeutic Virtual Reality Solution for Bone Marrow Biopsy (REVEH Trial): Open-Label, Randomized, Multicenter, Phase 3 Study Article de journal
Dans: Journal of Medical Internet Research, vol. 25, 2023, ISSN: 14388871 (ISSN), (Publisher: JMIR Publications Inc.).
Résumé | Liens | BibTeX | Étiquettes: 80 and over, Adolescent, adult, aged, alprazolam, Anxiety, article, Biopsy, blood pressure measurement, Bone Marrow, bone marrow biopsy, clinical trial, controlled study, demographics, digital health, digital therapeutics, Distraction, Effectiveness, efficacy, eHealth, female, follow up, head-mounted display, hematologic disease, human, human tissue, Humans, hypertension, imagery, imaginary, imagination, Immersive environment, Intention to Treat Analysis, interactive environment, leukemia, lidocaine, local anesthesia, lymphoma, major clinical study, male, medical procedure, Meopa, Middle Aged, monoclonal immunoglobulinemia, multicenter study, myelodysplastic syndrome, myeloma, myeloproliferative disorder, myeloproliferative neoplasm, nitrous oxide plus oxygen, open study, Pain, pain intensity, pain measurement, paracetamol, phase 3 clinical trial, prospective study, questionnaire, randomized controlled trial, RCT, relaxation training, safety, satisfaction, solid malignant neoplasm, State Trait Anxiety Inventory, very elderly, virtual reality, visual analog scale, VR, Young Adult
@article{le_du_new_2023,
title = {A New Option for Pain Prevention Using a Therapeutic Virtual Reality Solution for Bone Marrow Biopsy (REVEH Trial): Open-Label, Randomized, Multicenter, Phase 3 Study},
author = {K. Le Du and A. -L. Septans and F. Maloisel and H. Vanquaethem and A. Schmitt and M. Le Goff and A. Clavert and M. Zinger and H. Bourgeois and O. Dupuis and F. Denis and S. Bouchard},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148250546&doi=10.2196%2f38619&partnerID=40&md5=e27bfbd3d4c42f8850daf70bdf60b384},
doi = {10.2196/38619},
issn = {14388871 (ISSN)},
year = {2023},
date = {2023-01-01},
journal = {Journal of Medical Internet Research},
volume = {25},
abstract = {Background: Evidence regarding the analgesic effect of distraction through immersion in virtual reality (VR) for care-induced pain has been documented in several phase 2 trials, but comparison with standard treatments in large, randomized studies is needed. Objective: In this open-label, multicenter, randomized, phase 3 trial, we evaluated the safety and efficacy of a novel VR therapy solution for distraction in the context of bone marrow biopsy. Methods: Bliss is a VR software with 4 imaginary interactive environments in 3 dimensions with binaural sound (head-mounted display). Efficacy regarding pain intensity was evaluated using a visual analog scale (VAS; score from 0 to 10) immediately after the biopsy. Secondary end points were anxiety and tolerance. Modified intention-to-treat analysis was performed. Results: Overall, 126 patients with previously documented untreated or suspected malignant hemopathy between September 6, 2018, and May 18, 2020, were randomly assigned in a 1:1 ratio to receive pain prevention with a mixture of nitrous oxide/oxygen (MEOPA; n=63) or VR (n=63) before and during the bone marrow biopsy. We excluded 8 patients from the final analysis (3 in the MEOPA group and 5 in the VR group). All patients received local anesthesia (lidocaine) before biopsy. Follow-up was limited to 1 month after the biopsy. Participants' median age was 65.5 (range 18-87) years, and 54.2% (64/118) of patients were male. The average pain intensity was 3.5 (SD 2.6, 95% CI -1.6 to 8.6) for the MEOPA group and 3.0 (SD 2.4, 95% CI -1.7 to 7.7) for the VR group, without any significant differences in age, sex, center, and hemopathy (P=.26). Concerning anxiety, 67.5% (79/117; fear of pain questionnaire) of the patients were afraid before the biopsy, and anxiety scores were moderate to very high in 26.3% (30/114; revised Spielberger State-Trait Anxiety Inventory questionnaire) of the patients before the biopsy and 9.0% (10/114) after the biopsy for all patients, without a significant difference between the 2 groups (P=.83). Immersion in VR was well tolerated by the majority (54/57, 95%) of patients in the VR group. Conclusions: The intensity of pain did not significantly differ between both arms. VR was well tolerated, and the satisfaction of patients, nurses, and physicians was very high. VR could be an alternative treatment in case of contraindication or intolerance to MEOPA. © 2023 Journal of Medical Internet Research. All rights reserved.},
note = {Publisher: JMIR Publications Inc.},
keywords = {80 and over, Adolescent, adult, aged, alprazolam, Anxiety, article, Biopsy, blood pressure measurement, Bone Marrow, bone marrow biopsy, clinical trial, controlled study, demographics, digital health, digital therapeutics, Distraction, Effectiveness, efficacy, eHealth, female, follow up, head-mounted display, hematologic disease, human, human tissue, Humans, hypertension, imagery, imaginary, imagination, Immersive environment, Intention to Treat Analysis, interactive environment, leukemia, lidocaine, local anesthesia, lymphoma, major clinical study, male, medical procedure, Meopa, Middle Aged, monoclonal immunoglobulinemia, multicenter study, myelodysplastic syndrome, myeloma, myeloproliferative disorder, myeloproliferative neoplasm, nitrous oxide plus oxygen, open study, Pain, pain intensity, pain measurement, paracetamol, phase 3 clinical trial, prospective study, questionnaire, randomized controlled trial, RCT, relaxation training, safety, satisfaction, solid malignant neoplasm, State Trait Anxiety Inventory, very elderly, virtual reality, visual analog scale, VR, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Background: Evidence regarding the analgesic effect of distraction through immersion in virtual reality (VR) for care-induced pain has been documented in several phase 2 trials, but comparison with standard treatments in large, randomized studies is needed. Objective: In this open-label, multicenter, randomized, phase 3 trial, we evaluated the safety and efficacy of a novel VR therapy solution for distraction in the context of bone marrow biopsy. Methods: Bliss is a VR software with 4 imaginary interactive environments in 3 dimensions with binaural sound (head-mounted display). Efficacy regarding pain intensity was evaluated using a visual analog scale (VAS; score from 0 to 10) immediately after the biopsy. Secondary end points were anxiety and tolerance. Modified intention-to-treat analysis was performed. Results: Overall, 126 patients with previously documented untreated or suspected malignant hemopathy between September 6, 2018, and May 18, 2020, were randomly assigned in a 1:1 ratio to receive pain prevention with a mixture of nitrous oxide/oxygen (MEOPA; n=63) or VR (n=63) before and during the bone marrow biopsy. We excluded 8 patients from the final analysis (3 in the MEOPA group and 5 in the VR group). All patients received local anesthesia (lidocaine) before biopsy. Follow-up was limited to 1 month after the biopsy. Participants' median age was 65.5 (range 18-87) years, and 54.2% (64/118) of patients were male. The average pain intensity was 3.5 (SD 2.6, 95% CI -1.6 to 8.6) for the MEOPA group and 3.0 (SD 2.4, 95% CI -1.7 to 7.7) for the VR group, without any significant differences in age, sex, center, and hemopathy (P=.26). Concerning anxiety, 67.5% (79/117; fear of pain questionnaire) of the patients were afraid before the biopsy, and anxiety scores were moderate to very high in 26.3% (30/114; revised Spielberger State-Trait Anxiety Inventory questionnaire) of the patients before the biopsy and 9.0% (10/114) after the biopsy for all patients, without a significant difference between the 2 groups (P=.83). Immersion in VR was well tolerated by the majority (54/57, 95%) of patients in the VR group. Conclusions: The intensity of pain did not significantly differ between both arms. VR was well tolerated, and the satisfaction of patients, nurses, and physicians was very high. VR could be an alternative treatment in case of contraindication or intolerance to MEOPA. © 2023 Journal of Medical Internet Research. All rights reserved.
2.
Baus, O.; Bouchard, S.; Nolet, K.
Exposure to a pleasant odour may increase the sense of reality, but not the sense of presence or realism Article de journal
Dans: Behaviour and Information Technology, vol. 38, no 12, p. 1369–1378, 2019, ISSN: 0144929X (ISSN), (Publisher: Taylor and Francis Ltd.).
Résumé | Liens | BibTeX | Étiquettes: adult, Ambient air, apple, article, cinnamon, female, follow up, Fruits, human, human experiment, human tissue, male, nonhuman, odor, Odors, Odours, Olfaction, Presence, Realism, Reality, Sense of presences, urine, virtual reality, Visual scene
@article{baus_exposure_2019,
title = {Exposure to a pleasant odour may increase the sense of reality, but not the sense of presence or realism},
author = {O. Baus and S. Bouchard and K. Nolet},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062948876&doi=10.1080%2f0144929X.2019.1590458&partnerID=40&md5=b9a2badea1774db4c07a5d9b256614d3},
doi = {10.1080/0144929X.2019.1590458},
issn = {0144929X (ISSN)},
year = {2019},
date = {2019-01-01},
journal = {Behaviour and Information Technology},
volume = {38},
number = {12},
pages = {1369–1378},
abstract = {Smell can increase the sense of presence, reality, and realism when exposed in a virtual environment. This effect has been found to be increased when the nature of the odour is concordant visually with the scene, i.e. exposure to an unpleasant odour in a filthy virtual kitchen. The objective of this project was to verify whether this effect could be generalised to pleasant odours. Participants were immersed in a virtual apartment with a kitchen where the visual scene suggested that cinnamon apple pies had recently been baked. Participants were randomly and blindly assigned to three conditions: exposition to the ambient air, to a pleasant odour of cinnamon apple pie, or an unpleasant odour of urine. The results indicated that while exposure to the visually concordant pleasant odour did increase the sense of reality in a statistically significant manner, it did not affect the sense of presence or realism. Results also suggested that the visual/olfactory concordance may have facilitated the detection of the pleasant odour. The potential implications of the results, potential explanations for the lack of effect on the sense of presence, as well as potential follow-up research projects are discussed. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.},
note = {Publisher: Taylor and Francis Ltd.},
keywords = {adult, Ambient air, apple, article, cinnamon, female, follow up, Fruits, human, human experiment, human tissue, male, nonhuman, odor, Odors, Odours, Olfaction, Presence, Realism, Reality, Sense of presences, urine, virtual reality, Visual scene},
pubstate = {published},
tppubtype = {article}
}
Smell can increase the sense of presence, reality, and realism when exposed in a virtual environment. This effect has been found to be increased when the nature of the odour is concordant visually with the scene, i.e. exposure to an unpleasant odour in a filthy virtual kitchen. The objective of this project was to verify whether this effect could be generalised to pleasant odours. Participants were immersed in a virtual apartment with a kitchen where the visual scene suggested that cinnamon apple pies had recently been baked. Participants were randomly and blindly assigned to three conditions: exposition to the ambient air, to a pleasant odour of cinnamon apple pie, or an unpleasant odour of urine. The results indicated that while exposure to the visually concordant pleasant odour did increase the sense of reality in a statistically significant manner, it did not affect the sense of presence or realism. Results also suggested that the visual/olfactory concordance may have facilitated the detection of the pleasant odour. The potential implications of the results, potential explanations for the lack of effect on the sense of presence, as well as potential follow-up research projects are discussed. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.