@article{le_du_new_2023,

title = {A New Option for Pain Prevention Using a Therapeutic Virtual Reality Solution for Bone Marrow Biopsy (REVEH Trial): Open-Label, Randomized, Multicenter, Phase 3 Study},

author = {K. Le Du and A. -L. Septans and F. Maloisel and H. Vanquaethem and A. Schmitt and M. Le Goff and A. Clavert and M. Zinger and H. Bourgeois and O. Dupuis and F. Denis and S. Bouchard},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148250546&doi=10.2196%2f38619&partnerID=40&md5=e27bfbd3d4c42f8850daf70bdf60b384},

doi = {10.2196/38619},

issn = {14388871 (ISSN)},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Medical Internet Research},

volume = {25},

abstract = {Background: Evidence regarding the analgesic effect of distraction through immersion in virtual reality (VR) for care-induced pain has been documented in several phase 2 trials, but comparison with standard treatments in large, randomized studies is needed. Objective: In this open-label, multicenter, randomized, phase 3 trial, we evaluated the safety and efficacy of a novel VR therapy solution for distraction in the context of bone marrow biopsy. Methods: Bliss is a VR software with 4 imaginary interactive environments in 3 dimensions with binaural sound (head-mounted display). Efficacy regarding pain intensity was evaluated using a visual analog scale (VAS; score from 0 to 10) immediately after the biopsy. Secondary end points were anxiety and tolerance. Modified intention-to-treat analysis was performed. Results: Overall, 126 patients with previously documented untreated or suspected malignant hemopathy between September 6, 2018, and May 18, 2020, were randomly assigned in a 1:1 ratio to receive pain prevention with a mixture of nitrous oxide/oxygen (MEOPA; n=63) or VR (n=63) before and during the bone marrow biopsy. We excluded 8 patients from the final analysis (3 in the MEOPA group and 5 in the VR group). All patients received local anesthesia (lidocaine) before biopsy. Follow-up was limited to 1 month after the biopsy. Participants' median age was 65.5 (range 18-87) years, and 54.2% (64/118) of patients were male. The average pain intensity was 3.5 (SD 2.6, 95% CI -1.6 to 8.6) for the MEOPA group and 3.0 (SD 2.4, 95% CI -1.7 to 7.7) for the VR group, without any significant differences in age, sex, center, and hemopathy (P=.26). Concerning anxiety, 67.5% (79/117; fear of pain questionnaire) of the patients were afraid before the biopsy, and anxiety scores were moderate to very high in 26.3% (30/114; revised Spielberger State-Trait Anxiety Inventory questionnaire) of the patients before the biopsy and 9.0% (10/114) after the biopsy for all patients, without a significant difference between the 2 groups (P=.83). Immersion in VR was well tolerated by the majority (54/57, 95%) of patients in the VR group. Conclusions: The intensity of pain did not significantly differ between both arms. VR was well tolerated, and the satisfaction of patients, nurses, and physicians was very high. VR could be an alternative treatment in case of contraindication or intolerance to MEOPA. © 2023 Journal of Medical Internet Research. All rights reserved.},

note = {Publisher: JMIR Publications Inc.},

keywords = {80 and over, Adolescent, adult, aged, alprazolam, Anxiety, article, Biopsy, blood pressure measurement, Bone Marrow, bone marrow biopsy, clinical trial, controlled study, demographics, digital health, digital therapeutics, Distraction, Effectiveness, efficacy, eHealth, female, follow up, head-mounted display, hematologic disease, human, human tissue, Humans, hypertension, imagery, imaginary, imagination, Immersive environment, Intention to Treat Analysis, interactive environment, leukemia, lidocaine, local anesthesia, lymphoma, major clinical study, male, medical procedure, Meopa, Middle Aged, monoclonal immunoglobulinemia, multicenter study, myelodysplastic syndrome, myeloma, myeloproliferative disorder, myeloproliferative neoplasm, nitrous oxide plus oxygen, open study, Pain, pain intensity, pain measurement, paracetamol, phase 3 clinical trial, prospective study, questionnaire, randomized controlled trial, RCT, relaxation training, safety, satisfaction, solid malignant neoplasm, State Trait Anxiety Inventory, very elderly, virtual reality, visual analog scale, VR, Young Adult},

pubstate = {published},

tppubtype = {article}

}

@article{clemmensen_study_2020,

title = {Study protocol: Exposure in virtual reality for social anxiety disorder-a randomized controlled superiority trial comparing cognitive behavioral therapy with virtual reality based exposure to cognitive behavioral therapy with in vivo exposure},

author = {L. Clemmensen and S. Bouchard and J. Rasmussen and T. T. Holmberg and J. H. Nielsen and J. R. Mø. Jepsen and M. B. Lichtenstein},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078711155&doi=10.1186%2fs12888-020-2453-4&partnerID=40&md5=28b076f10bf189f7c90b8bed4c719200},

doi = {10.1186/s12888-020-2453-4},

issn = {1471244X},

year  = {2020},

date = {2020-01-01},

journal = {BMC Psychiatry},

volume = {20},

number = {1},

abstract = {Background: Social Anxiety Disorder (SAD) is characterized by an intense fear of negative judgement by others. Cognitive Behavioral Therapy (CBT) is recommended for treatment, but a substantial part of individuals with SAD either do not seek treatment or drop-out. CBT with Virtual Reality (VR)-based exposure has several advantages compared to traditional exposure methods, mainly due to increased control of situational elements. The aim of the current study is to develop a CBT program containing VR-based exposure. The intervention is targeted to adult patients suffering from SAD and treatment effect will be assessed by changes in SAD symptoms. Methods: This article describes the study protocol of a Randomized Controlled Trial with three arms: 1) CBT with VR exposure based on 360° videos 2) CBT with in vivo exposure and 3) VR relaxation therapy. There will be 30 participants in each arm with a crossover at the end of the treatment period during which the participants in the third group will be randomly re-Allocated to one of the two former groups. The treatment program consists of 10 weekly individual sessions with a psychologist, and a six month follow-up consisting of a questionnaire. The primary outcome measure is reduction in SAD symptoms which will be assessed with the Social Interaction Anxiety Scale (SIAS). Discussion: There are currently no published studies on CBT with VR exposure based on 360° videos for SAD treatment. Furthermore, the current study will be the first Danish SAD treatment program that includes VR technology. Trial registration: clinicaltrials.gov (NCT03973541) June 3rd 2019. © 2020 The Author(s).},

note = {Publisher: BioMed Central},

keywords = {adult, Anxiety, article, clinical effectiveness, cognitive behavioral therapy, controlled study, exposure, follow up, health program, human, Humans, in vivo study, outcome assessment, phobia, psychologist, questionnaire, randomized controlled trial, relaxation training, Social, Social Interaction Anxiety Scale, social phobia, treatment outcome, virtual reality, virtual reality exposure therapy, Young Adult},

pubstate = {published},

tppubtype = {article}

}

@article{grenier_using_2015,

title = {Using virtual reality to improve the efficacy of cognitive-behavioral therapy (CBT) in the treatment of late-life anxiety: Preliminary recommendations for future research},

author = {S. Grenier and H. Forget and S. Bouchard and S. Isere and S. Belleville and O. Potvin and M. -È. Rioux and M. Talbot and N. A. Pachana and R. C. Oude Voshaar},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84931830085&doi=10.1017%2fS1041610214002300&partnerID=40&md5=6a937a7a7f13fca31c84fc7859b365d0},

doi = {10.1017/S1041610214002300},

issn = {10416102},

year  = {2015},

date = {2015-01-01},

journal = {International Psychogeriatrics},

volume = {27},

number = {7},

pages = {1217–1225},

abstract = {Cognitive-behavioral therapy (CBT) using traditional exposure techniques (i.e. imaginal and in vivo) seems less effective to treat anxiety in older adults than in younger ones. This is particularly true when imaginal exposure is used to confront the older patient to inaccessible (e.g. fear of flying) or less tangible/controllable anxiety triggers (e.g. fear of illness). Indeed, imaginal exposure may become less effective as the person gets older since normal aging is characterized by the decline in cognitive functions involved in the creation of vivid/detailed mental images. One way to circumvent this difficulty is to expose the older patient to a virtual environment that does not require the ability to imagine the frightening situation. In virtuo exposure has proven to be efficient to treat anxiety in working-age people. In virtuo exposure could be employed to improve the efficacy of CBT with exposure sessions in the treatment of late-life anxiety? The current paper explores this question and suggests new research avenues. Copyright © International Psychogeriatric Association 2014.},

note = {Publisher: Cambridge University Press},

keywords = {adult, aged, aging, Anxiety, Anxiety disorder, Anxiety Disorders, clinical effectiveness, cognition, cognitive defect, cognitive therapy, Depression, disease association, exposure, Fear, generalized anxiety disorder, gerontopsychiatry, human, Humans, late life anxiety disorder, panic, patient counseling, posttraumatic stress disorder, procedures, psychology, randomized controlled trial (topic), relaxation training, Research, review, Social Support, treatment outcome, trends, virtual reality, virtual reality exposure therapy},

pubstate = {published},

tppubtype = {article}

}

@article{stetz_effectiveness_2011,

title = {The effectiveness of Technology-Enhanced relaxation techniques for military medical warriors},

author = {M. C. Stetz and J. Y. Kaloi-Chen and D. D. Turner and S. Bouchard and G. Riva and B. K. Wiederhold},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052455147&doi=10.7205%2fMILMED-D-10-00393&partnerID=40&md5=dce993c0b65bb351edd74816a0d65450},

doi = {10.7205/MILMED-D-10-00393},

issn = {00264075},

year  = {2011},

date = {2011-01-01},

journal = {Military Medicine},

volume = {176},

number = {9},

pages = {1065–1070},

abstract = {Combat zones can be very stressful for those in the area. Even in the battlefi eld, military medical personnel are expected to save others, while also staying alive. In this study, half of a sample of deployed military medical warriors (total n = 60) participated in technology-assisted relaxation training. Learning relaxation skills with a video clip of virtual reality relaxing scenes showed a statistically signifi cant impact on the anxiety levels of the Experimental Group. © Association of Military Surgeons of the U.S. All rights reserved.},

note = {Publisher: Association of Military Surgeons of the US},

keywords = {adult, Anxiety, article, clinical trial, computer interface, controlled clinical trial, controlled study, female, human, Humans, male, mental stress, methodology, Military Personnel, Psychological, psychological aspect, questionnaire, Questionnaires, randomized controlled trial, Relaxation Therapy, relaxation training, soldier, Stress, User-Computer Interface, Video recording, videorecording},

pubstate = {published},

tppubtype = {article}

}

@article{stetz_receptiveness_2009,

title = {The receptiveness of stress management techniques by military personnel},

author = {M. C. Stetz and S. Bouchard and B. K. Wiederhold and G. Riva and R. A. Folen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-77949756841&partnerID=40&md5=bc79a1859b04215c00beaa9b43be8011},

doi = {10.3233/978-1-60750-017-9-125},

issn = {15548716},

year  = {2009},

date = {2009-01-01},

journal = {Annual Review of CyberTherapy and Telemedicine},

volume = {7},

number = {1},

pages = {125–127},

abstract = {Many military service members suffer from stress. Sixty Soldiers participated in a study designed to test receptivity to stress management techniques. Preliminary analyses of surveys and a focus group suggested that participants not only liked practicing relaxation techniques but would also continue practicing these after completion of the present study.},

note = {ISBN: 9781607500179 

Publisher: IOS Press},

keywords = {adult, article, controlled study, Counseling, emotion, Emotions, female, Focus groups, human, Human resource management, Humans, Industrial management, major clinical study, male, mental stress, Military Personnel, Military personnels, Military services, perception, Preliminary analysis, Psychological, questionnaire, Relaxation techniques, relaxation training, soldier, Stress, Stress management, Surveys, Surveys and Questionnaires, technique, virtual reality},

pubstate = {published},

tppubtype = {article}

}

@article{dugas_cognitive_2009,

title = {Cognitive behavioural therapy and applied relaxation for generalized anxiety disorder: A time series analysis of change in worry and somatic anxiety},

author = {M. J. Dugas and K. Francis and S. Bouchard},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-61549090786&doi=10.1080%2f16506070802473221&partnerID=40&md5=78e775f09aa9806132cd1335ffef92b6},

doi = {10.1080/16506070802473221},

issn = {16512316 (ISSN)},

year  = {2009},

date = {2009-01-01},

journal = {Cognitive Behaviour Therapy},

volume = {38},

number = {1},

pages = {29–41},

abstract = {The present study examined symptom change profiles in patients with generalized anxiety disorder (GAD) receiving either cognitive behavioural therapy (CBT) or applied relaxation (AR). It was hypothesized that (a) changes in worry would uniquely predict changes in somatic anxiety for most participants receiving CBT and (b) changes in somatic anxiety would uniquely predict changes in worry for most participants in the AR condition. Twenty participants (CBT n = 10; AR n = 10) completed daily ratings of worry and somatic anxiety during therapy, and multivariate time series analysis was used to assess the causal impact of each variable on the other. The hypotheses were not supported because we found no evidence of a match between individual symptom change profiles and treatment condition. Rather, a bidirectional relationship between worry and somatic anxiety was observed in 80% of participants receiving CBT and 70% of participants receiving AR. When only treatment responders were considered, 83% of participants receiving CBT and 86% of those receiving AR had such a bidirectional effect. The findings are discussed in terms of models of psychopathology that posit dynamic interactions between symptom clusters and in terms of the value of examining treatment mechanisms at the individual level.},

keywords = {adult, Anxiety Disorders, article, clinical article, clinical trial, cognitive therapy, controlled clinical trial, controlled study, disease association, female, generalized anxiety disorder, human, Humans, male, mental stress, Middle Aged, Personality Assessment, Personality Inventory, psychoanalysis, Psychometrics, randomized controlled trial, Relaxation Therapy, relaxation training, Single-case designs, somatoform disorder, Somatoform Disorders, Symptom change profiles, symptomatology, time series analysis, Treatment mechanisms, treatment outcome, treatment response},

pubstate = {published},

tppubtype = {article}

}