@article{cote_eyes_2026,

title = {The eyes are central to face detection: revisiting the foundations of face processing},

author = {L. Côté and J. Lamontagne and A. Bellerose and C. Blais and D. Fiset},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105030389147&doi=10.1016%2Fj.visres.2026.108785&partnerID=40&md5=752aa5d9923ac60539e36118ad41e1e6},

doi = {10.1016/j.visres.2026.108785},

issn = {00426989 (ISSN)},

year  = {2026},

date = {2026-01-01},

journal = {Vision Research},

volume = {243},

abstract = {Face detection feels effortless, yet it requires finely tuned computations to extract socially meaningful signals from the visual stream. Here, we used the Bubbles method to isolate the facial features and spatial frequency information that support face categorization. Across three experiments varying in task demands and visual context, the eye region consistently emerged as the most diagnostic source of information, particularly in high spatial frequencies. This finding held whether participants distinguished faces from noise, from non-face objects, or from real-world categories—suggesting that the eyes serve as an anchor point for categorization across contexts. Strikingly, this diagnostic profile mirrors that found in face identification tasks, implying that detection and recognition may rely on shared perceptual mechanisms rather than sequential, independent processes. This overlap sheds light on longstanding ambiguities in the prosopagnosia literature, indicating that detection impairments found in patients may stem from a broader failure to extract critical eye information. More broadly, our results invite a rethinking of the early stages of face processing, suggesting that detection already involves selective use of diagnostic facial features that supports recognition, emotional decoding, and social perception. © 2026 The Author(s).},

keywords = {adult, article, Black person, Bubbles, Categorization, Caucasian, Detection, emotion assessment, Faces, Facial Recognition, facies, female, human, human experiment, Image analysis, information processing, Information use, male, Noise, normal human, perception, Prosopagnosia, spatial frequency discrimination, task performance, visual discrimination, Young Adult},

pubstate = {published},

tppubtype = {article}

}

@article{delangle_speaking_2026,

title = {Speaking face-to-face with a virtual avatar to reduce anxiety in students who stutter: Tool development and pilot study results},

author = {M. Delangle and A. Moïse-Richard and A. -L. Leclercq and D. Labbé and S. Bouchard and S. Andrews and L. Ménard},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105028302364&doi=10.1016%2Fj.jfludis.2026.106194&partnerID=40&md5=af0d246f9187ee19796f36456887400b},

doi = {10.1016/j.jfludis.2026.106194},

issn = {0094730X (ISSN)},

year  = {2026},

date = {2026-01-01},

journal = {Journal of Fluency Disorders},

volume = {87},

abstract = {Purpose Speaking in class is challenging for students who stutter. Cognitive-behavioral therapy (CBT) with exposure in virtual reality (VR) emerges as a promising intervention for treating speaking anxiety in pediatric populations. This pilot study tested if real-time avatar-based VR can elicit anxiety responses while remaining acceptable to youth who stutter. Method Twelve students who stutter (aged 9–18) were randomly assigned to a single training session conducted either (1) in VR with a realistic avatar controlled live by their SLP, or (2) in role-play with their SLP, before facing a real actor. We assessed system acceptability, anxiety levels and perceived self-efficacy. Results The VR system was well accepted and elicited physiological arousal comparable to real-life interactions. Although participants reported experiencing less anxiety during VR, skin conductance level showed higher arousal; suggesting a divergence between the subjective report and physiological response. Finally, one training session (either in VR or with the SLP) did not produce gains in self-efficacy or decrease in anxiety related to the final real-actor conversation. Conclusion This study demonstrates evidence that the potential use of immersive VR could represent an acceptable and viable complementary strategy for SLP treatment, that could control exposure parameters while evoking physiological responses similar to real-life contexts. The differences between subjective and physiological measures suggest that VR is inducing anxiety responses differently than it was perceived. Further research could investigate the use of VR as anxiety interventions for students who stutter and should be explored across multi-session studies to understand their therapeutic effect. © 2026 The Authors.},

keywords = {Adolescent, adult, Anxiety, Arousal, article, Avatar, avoidance behavior, Canada, Child, clinical article, cognitive behavioral therapy, complication, controlled study, distance learning, ecological validity, electrocardiogram, electrodermal response, exposure, female, Heart Rate, heart rate variability, human, Humans, Liebowitz Social Anxiety Scale, Likert scale, male, nonverbal communication, physiological stress, Pilot Projects, pilot study, procedures, psychology, questionnaire, randomized controlled trial, role playing, School-age children, Self Concept, Self Efficacy, self report, Signal processing, skin conductance, social anxiety, speech, student, Students, Stuttering, Therapy, treatment outcome, virtual reality, virtual reality exposure therapy},

pubstate = {published},

tppubtype = {article}

}

@article{onita_virtual_2025,

title = {Virtual Reality Trier Social Stress and Virtual Supermarket Exposure: Electrocardiogram Correlates of Food Craving and Eating Traits in Adolescents},

author = {C. A. Onita and D. -V. Matei and E. Chelarasu and R. G. Lupu and D. Petrescu-Miron and A. Visnevschi and S. Vudu and C. Corciova and R. Fuior and N. Tupita and S. Bouchard and V. Mocanu},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105026068857&doi=10.3390%2Fnu17243924&partnerID=40&md5=fde16e892b1a18284dc51ac869ba8ee9},

doi = {10.3390/nu17243924},

issn = {20726643 (ISSN)},

year  = {2025},

date = {2025-01-01},

journal = {Nutrients},

volume = {17},

number = {24},

abstract = {Background/Objectives: Acute stress is known to influence food-related motivation and decision-making, often promoting a preference for energy-dense, palatable foods. However, traditional laboratory paradigms have limited ecological validity. This study examined the relationship between stress-induced physiological changes, eating behavior traits, and food cravings using a virtual reality (VR) adaptation of the Trier Social Stress Test (VR-TSST) followed by a VR supermarket task in adolescents. Methods: Thirty-eight adolescents (mean age 15.8 ± 0.6 years) participated in the study. Physiological parameters (HR, QT, PQ intervals) were recorded pre- and post-stress using a portable ECG device (WIWE). Perceived stress and eating behavior traits were evaluated with the Perceived Stress Scale (PSS) and the Three-Factor Eating Questionnaire (TFEQ-R21C), respectively. Immediately after the VR-TSST, participants performed a VR supermarket task in which they rated cravings for sweet, fatty, and healthy foods using visual analog scales (VAS). Paired-samples t-tests examined pre–post changes in physiological parameters, partial correlations explored associations between ECG responses and eating traits, and a 2 × 3 mixed-model Repeated Measures ANOVA assessed the effects of food type (sweet, fatty, healthy) and uncontrolled eating (UE) group (low vs. high) on post-stress cravings. Results: Acute stress induced significant increases in HR and QTc intervals (p < 0.01), confirming a robust physiological stress response. The ANOVA revealed a strong main effect of food type (F(1.93, 435.41) = 168.98, p < 0.001, η2p = 0.43), indicating that stress-induced cravings differed across food categories, with sweet foods rated highest. A significant food type × UE group interaction (F(1.93, 435.41) = 16.49, p < 0.001, η2p = 0.07) showed that adolescents with high UE exhibited greater cravings for sweet and fatty foods than those with low UE. Overall, craving levels did not differ significantly between groups. Conclusions: The findings demonstrate that acute stress selectively enhances cravings for high-reward foods, and that this effect is modulated by baseline uncontrolled eating tendencies. The combined use of VR-based stress induction and VR supermarket simulation offers an innovative, ecologically valid framework for studying stress-related eating behavior in adolescents, with potential implications for personalized nutrition and the prevention of stress-induced overeating. © 2025 by the authors.},

keywords = {acute stress, Adolescent, Adolescents, adult, article, controlled study, craving, decision making, Eating, eating behavior, ecological validity, electrocardiogram, electrocardiogram (ECG) parameters, Electrocardiography, feeding behavior, female, food craving, food preference, Food Preferences, Heart Rate, human, Humans, hyperphagia, male, mental stress, motivation, normal human, overnutrition, pathophysiology, Perceived Stress Scale, personalized nutrition, physiological stress, physiology, PQ interval, Psychological, psychology, QTc interval, questionnaire, reward, simulation, social stress, Stress, supermarket, Surveys and Questionnaires, three-factor eating questionnaire (TFEQ), Three-Factor-Eating-Questionnaire, Trier Social Stress Test, virtual reality, virtual supermarket, visual analog scale},

pubstate = {published},

tppubtype = {article}

}

@article{sheehy_immersive_2025,

title = {Immersive Virtual Reality Experiences can Decrease Pain and Distress in Patients Living in Complex Care},

author = {L. Sheehy and H. Finestone and S. Bouchard and K. Dezeeuw and P. Doering and N. Dunlop and H. Sveistrup},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105023893911&partnerID=40&md5=cf29113c44db0b13e00df2e34acbc141},

issn = {15548716 (ISSN)},

year  = {2025},

date = {2025-01-01},

journal = {Annual Review of CyberTherapy and Telemedicine},

volume = {23},

pages = {272–278},

abstract = {Patients living in complex care (CC) frequently experience pain. The study goals were to assess the feasibility of using virtual reality (VR), and the potential for VR to impact pain, mood, and quality of life in two groups of patients living in CC, those experiencing acute pain during wound dressing changes and those experiencing chronic pain. Participants were offered 30 minutes of immersive, passive VR experiences using a Meta Quest 2 headset, 3 times/week for 3 weeks. Pain and mood were assessed pre, during and post each VR session. Pain, mood and quality of life were assessed before and after the 3-week intervention. Feasibility was assessed after each session. Three women (average age 66.3) with wound dressing changes completed an average of 3.7 sessions (25.5 minutes/session). Two-thirds experienced meaningful declines in pain with VR. Seventeen participants (6 men, 11 women, average age 58.4) with chronic pain completed an average of 3.1 sessions (21.4 minutes/session). Pain was significantly decreased from pre to post VR and pre to during VR. Mood and quality of life did not change. Both groups had low levels of discomfort and nausea, and high levels of satisfaction and immersiveness. Most participants enjoyed the experience and appreciated the immersion. It was challenging to adapt the headset to patients in non-seated positions who could not use VR controllers. VR is a promising modality to manage pain in patients living in CC. More work needs to be done to confirm the results and implement VR in clinical settings. © 2025, Interactive Media Institute. All rights reserved.},

keywords = {adult, aged, article, chronic pain, clinical article, complex care, controlled study, discomfort, distress syndrome, female, human, immersion, male, Mood, nausea, Pain, patient care, quality of life, virtual reality, wound care},

pubstate = {published},

tppubtype = {article}

}

@article{bourbeau_role_2025,

title = {The Role of Body Image Perception on a Continuum from Dysfunctional to Healthy Eating Attitudes and Behaviors Among People Seeking Treatment},

author = {F. Bourbeau and S. Bouchard and G. Corno and J. Monthuy-Blanc},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216120423&doi=10.3390%2Fjcm14020597&partnerID=40&md5=be414bf29fdc6264d47a9c696954c80f},

doi = {10.3390/jcm14020597},

issn = {20770383 (ISSN)},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Clinical Medicine},

volume = {14},

number = {2},

abstract = {Background: Body image disturbance has been associated with various health conditions and has the potential to trigger the development of unhealthy behaviors, including dysfunctional attitudes and eating behaviors, which may evolve into eating disorders. This study explores the relationship between body image variables—such as global self-worth, physical self-worth, and physical attractiveness—and the continuum of eating attitudes and behaviors. Methods: A canonical correlation analysis was performed to assess the multivariate relationship between attitudinal and perceptual variables and the continuum of eating behaviors, with a total of 113 cases analyzed. Results: The findings indicate that intuitive eating and a positive body image (including global self-worth and physical attractiveness) are most strongly associated with the functional end of the continuum, while disordered eating behaviors and body dissatisfaction are linked to the dysfunctional end. Conclusions: These results suggest that interventions targeting the emotional and attitudinal dimensions of body dissatisfaction, whether delivered in vivo or via virtual reality (e.g., weight exposure), may facilitate a shift toward healthier, more functional eating behaviors along the continuum. © 2025 by the authors.},

note = {Publisher: Multidisciplinary Digital Publishing Institute (MDPI)},

keywords = {Adolescent, adult, aged, article, Attitude, behavior, body dissatisfaction, body dysmorphic disorder, body image, body image perception, body mass, correlation analysis, eating and attitudes and behaviors, eating disorder, Eating Disorder Examination Questionnaire, eating disorder inventory, eating habit, feeding behavior, female, healthy diet, healthy lifestyle, help seeking behavior, human, intuitive eating, major clinical study, male, Middle Aged, perception, physical attractiveness, psychological rating scale, retrospective study, Self Concept, self esteem, very elderly, virtual reality, Young Adult},

pubstate = {published},

tppubtype = {article}

}

@article{larochelle_intolerance_2025,

title = {Intolerance of Uncertainty and Emotion Dysregulation as Predictors of Generalized Anxiety Disorder Severity in a Clinical Population},

author = {S. Larochelle and M. J. Dugas and F. Langlois and P. Gosselin and G. Belleville and S. Bouchard},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000587548&doi=10.3390%2Fjcm14051502&partnerID=40&md5=7a364fe831d85eff0f0f7121657649e5},

doi = {10.3390/jcm14051502},

issn = {20770383 (ISSN)},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Clinical Medicine},

volume = {14},

number = {5},

abstract = {Background/objectives: Several factors have been shown to play a role in the development and maintenance of generalized anxiety disorder (GAD), including intolerance of uncertainty and emotion dysregulation. Although the individual contribution of both of these factors is well documented, their combined effect has yet to be studied in a clinical population with GAD. The aim of the present study was to examine the relative contribution of intolerance of uncertainty and emotion dysregulation to the prediction of worry and GAD severity in adults with GAD. Methods: The sample consisted of 108 participants diagnosed with GAD. The participants completed measures of worry, GAD severity, depressive symptoms, intolerance of uncertainty, and emotion dysregulation. Results: Multiple regression indicated that both intolerance of uncertainty and emotion dysregulation significantly contributed to both worry and GAD severity, over and above the contribution of depressive symptoms. Of note, the model explained 36% of the variance in GAD severity scores. Conclusions: The present results provide preliminary evidence of complementarity among dominant models of GAD, and point to the potential role of integrative conceptualizations and treatment strategies for GAD. © 2025 by the authors.},

note = {Publisher: Multidisciplinary Digital Publishing Institute (MDPI)},

keywords = {adult, aged, article, Beck Depression Inventory, clinical population, comorbidity, controlled study, Depression, difficulties in emotion regulation scale, disease severity, emotion, emotion dysregulation, emotion regulation, employment status, female, generalized anxiety disorder, human, intolerance of uncertainty, Intolerance of Uncertainty Scale, major clinical study, male, patient worry, penn state worry questionnaire, prediction, predictive model, psychotherapy, Severity of Illness Index, sociodemographics, theoretical model},

pubstate = {published},

tppubtype = {article}

}

@article{charbonneau_facial_2025,

title = {Facial expression categorization predominantly relies on mid-spatial frequencies},

author = {I. Charbonneau and J. Duncan and C. Blais and J. Guérette and M. -P. Plouffe-Demers and F. Smith and D. Fiset},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105003427898&doi=10.1016%2Fj.visres.2025.108611&partnerID=40&md5=508d315d8092a9142c2d82f1b774cfdb},

doi = {10.1016/j.visres.2025.108611},

issn = {00426989 (ISSN)},

year  = {2025},

date = {2025-01-01},

journal = {Vision Research},

volume = {231},

abstract = {Facial expressions are crucial in human communication. Recent decades have seen growing interest in understanding the role of spatial frequencies (SFs) in emotion perception in others. While some studies have suggested a preferential treatment of low versus high SFs, the optimal SFs for recognizing basic facial expressions remain elusive. This study, conducted on Western participants, addresses this gap using two complementary methods: a data-driven method (Exp. 1) without arbitrary SF cut-offs, and a more naturalistic method (Exp. 2) simulating variations in viewing distance. Results generally showed a preponderant role of low over high SFs, but particularly stress that facial expression categorization mostly relies on mid-range SF content (i.e. ∼6–13 cycles per face), often overlooked in previous studies. Optimal performance was observed at short to medium viewing distances (1.2–2.4 m), declining sharply with increased distance, precisely when mid-range SFs were no longer available. Additionally, our data suggest variations in SF tuning profiles across basic facial expressions and nuanced contributions from low and mid SFs in facial expression processing. Most importantly, it suggests that any method that removes mid-SF content has the downfall of offering an incomplete account of SFs diagnosticity for facial expression recognition. © 2025 The Authors},

note = {Publisher: Elsevier Ltd},

keywords = {adult, article, Bubbles, Classification, controlled study, emotion, Emotions, Facial Expression, facial expressions, Facial Recognition, female, human, Humans, male, physiology, Psychophysics, simulation, Spatial frequencies, Young Adult},

pubstate = {published},

tppubtype = {article}

}

@article{onita_autonomic_2025,

title = {Autonomic and Neuroendocrine Reactivity to VR Game Exposure in Children and Adolescents with Obesity: A Factor Analytic Approach to Physiological Reactivity and Eating Behavior},

author = {C. A. Onita and D. -V. Matei and L. -M. Trandafir and D. Petrescu-Miron and C. Corciova and R. Fuior and L. -M. Manole and B. -M. Mihai and C. -G. Dascalu and M. Tarcea and S. Bouchard and V. Mocanu},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105013574948&doi=10.3390%2Fnu17152492&partnerID=40&md5=d1e974dae00d424b9f6fae86b8a7cc6a},

doi = {10.3390/nu17152492},

issn = {20726643 (ISSN)},

year  = {2025},

date = {2025-01-01},

journal = {Nutrients},

volume = {17},

number = {15},

abstract = {Background/Objectives: The aim was to identify patterns of autonomic and neuroendocrine reactivity to an immersive virtual reality (VR) social-emotional stressor and explore their associations with perceived stress and eating behavior. Methods: This one-group pretest–posttest study included 30 children and adolescents with obesity (15 boys and 15 girls), aged 8 to 17 years. The VR protocol consisted of two consecutive phases: a 5 min relaxation phase using the Forest application and a 5 min stimulation phase using a cognitively engaging VR game designed to elicit social-emotional stress. Physiological responses were measured using heart rate variability (HRV) indices and salivary stress biomarkers, including cortisol and alpha amylase. Subjective stress and eating responses were assessed via visual analogue scales (VAS) administered immediately post-exposure. The Three-Factor Eating Questionnaire (TFEQ-R21C) was used to evaluate cognitive restraint (CR), uncontrolled eating (UE), and emotional eating (EE). Results: The cortisol reactivity was blunted and may reflect both the attenuated HPA axis responsiveness characteristic of pediatric obesity and the moderate psychological challenge of the VR stressor used in this study. Two distinct autonomic response patterns were identified via exploratory factor analysis: (1) parasympathetic reactivity, associated with increased RMSSD and SDNN and decreased LF/HF, and (2) sympathetic activation, associated with increased heart rate and alpha-amylase levels and reduced RR intervals. Parasympathetic reactivity was correlated with lower perceived stress and anxiety, but also paradoxically with higher uncontrolled eating (UE). In contrast, sympathetic activation was associated with greater cognitive restraint (CR) and higher anxiety ratings. Conclusions: This study demonstrates that immersive VR game exposure elicits measurable autonomic and subjective stress responses in children and adolescents with obesity, and that individual differences in physiological reactivity are relevantly associated with eating behavior traits. The findings suggest that parasympathetic and sympathetic profiles may represent distinct behavioral patterns with implications for targeted intervention. © 2025 by the authors.},

keywords = {Adolescent, adolescent obesity, alpha amylase saliva isoenzyme, alpha-Amylases, amylase, anthropometry, anxiety assessment, appetite, article, Autonomic Nervous System, autonomic nervous system function, chemistry, Child, childhood obesity, clinical article, controlled study, craving, eating behavior, Electrophysiology, emotional eating, emotional stress, exploratory factor analysis, Factor Analysis, feeding behavior, female, Heart Rate, heart rate variability, human, Humans, Hydrocortisone, hypothalamus hypophysis adrenal system, immersive VR game, male, mental stress, metabolism, neuroendocrine system, Neurosecretory Systems, pathophysiology, Pediatric Obesity, physiology, Psychological, psychology, Saliva, salivary alpha-amylase, salivary cortisol, social stress, Statistical, Stress, stress assessment, subjective stress, three-factor eating questionnaire (TFEQ), Three-Factor-Eating-Questionnaire, video game, Video Games, virtual reality, virtual reality exposure therapy, visual analog scale},

pubstate = {published},

tppubtype = {article}

}

@article{bouchard_conducting_2025,

title = {Conducting exposure in virtual reality for the treatment of social phobia does lead to change in dysfunctional beliefs},

author = {S. Bouchard and H. Forget},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105023856314&partnerID=40&md5=db4c4e86d7c32b544fe28c7fb6f9172b},

issn = {15548716 (ISSN)},

year  = {2025},

date = {2025-01-01},

journal = {Annual Review of CyberTherapy and Telemedicine},

volume = {23},

pages = {258–264},

abstract = {This study used data from a randomized control trial on cognitive behavior therapy for social phobia testing the effectiveness of exposure conducted in virtual reality. Measures of cognitive mechanisms had been collected but never analyzed. The study was motivated by a recent publication mentioning that potential aversive outcomes of being judged in virtual reality and by virtual characters have no objective negative consequence in daily life. A sample of 51 adults completed outcome and cognitive mechanism measures at a pretreatment, after 14 weeks of treatment or being on a waiting list, and at a 6-month follow-up. Results demonstrate that conducting exposure in virtual reality led to reductions in dysfunctional beliefs about the perceived consequences of feared social threats, about the likelihood of these feared threats occurring, as well as an increase in perceived self-efficacy to face social situations. These changes were statistically significant when compared to the waiting list condition, remained stable at the 6-month follow-up, and were no less important than when exposure was conducted in vivo. All predictors significantly correlated (p < .001) with the two measures of treatment outcome. Further analyses of cognitive mechanism measures predicting treatment outcomes revealed that, when controlling for shared variance, changes in perceived likelihood and in self-efficacy contributed significantly to patients’ improvement, whereas the role of perceived consequences was only a predictor of self-efficacy. © 2025, Interactive Media Institute. All rights reserved.},

keywords = {adult, article, clinical article, cognitive behavioral therapy, controlled study, exposure, female, follow up, hospital admission, human, in vivo study, Liebowitz Social Anxiety Scale, male, multiple regression, predictors of outcome, randomized controlled trial, social anxiety disorder, social phobia, Social Phobia Scale, threat, treatment duration, Treatment mechanisms, treatment outcome, virtual reality},

pubstate = {published},

tppubtype = {article}

}

@article{yee_cognitive_2025,

title = {Cognitive Remediation for Psychosis in Virtual Reality (ThinkTactic VR): Qualitative, Iterative, and User-Centered Codevelopment Study},

author = {J. Yee and H. Matheson and B. J. M. Bogie and É. D. Perron and A. Thérond and M. Charest and C. Driel and M. Goyette and Y. T. Lei and C. Noël and K. Ariaratnam and G. Collins and C. Gorman and A. -M. Cretu and S. Tremblay and M. -C. Rivard and C. Cullwick and C. Morris and D. G. Attwood and A. Baines and A. Stewart and S. Bouchard and C. R. Bowie and S. Guimond},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105013110717&doi=10.2196%2F69359&partnerID=40&md5=c5daaabcfd92d826b28327a5800609ae},

doi = {10.2196/69359},

issn = {23687959 (ISSN)},

year  = {2025},

date = {2025-01-01},

journal = {JMIR Mental Health},

volume = {12},

abstract = {Background: Cognitive remediation improves cognition and psychosocial functioning in individuals with psychotic disorders. The use of virtual reality (VR) to deliver cognitive remediation in immersive environments that mimic real cognitively challenging situations has the potential to increase engagement to treatment and further enhance its impact on functioning. Objective: We aimed to codevelop a cognitive remediation program in VR with individuals with psychotic disorders and health care professionals to identify and address their needs. Methods: Individuals with lived experience of a psychosis-spectrum condition (n=11) met 9 times and the health care professionals (n=7) met 3 times. Participants discussed personal and professional opinions on the challenges associated with cognitive difficulties in individuals with psychotic disorders. They also provided feedback on the program development. Results: We discerned 4 themes from the content expert working groups: the need for a program to address cognitive impairments, the key program design elements to support cognitive rehabilitation, the importance of leveraging technology as an intervention tool, and the need to improve community functioning. In total, 3 themes were identified for the health care professionals: the need for a clinically relevant program that addresses the research-to-practice gap, the need to improve patient engagement in services, and the need for a program that addresses the limited resources in health care. The needs of our end-user experts were placed at the center of the program development process. When possible, we also integrated their suggestions, like the incorporation of a virtual coach within the immersive environment. Conclusions: Individuals with lived experience and health care professionals have distinct needs, which have informed the co-design of a novel cognitive remediation program in VR, ThinkTactic VR. To our knowledge, ThinkTactic VR is one of the first co-designed and codeveloped cognitive remediation programs in VR using an iterative, user-centered approach involving both individuals with psychotic disorders and health care professionals. ©Jasmin Yee, Hannah Matheson, Bryce J M Bogie, Émilie Du Perron, Alexandra Thérond, Maëlle Charest, Catheleine van Driel, Marika Goyette, Ya Ting Lei, Chelsea Noël, Kagusthan Ariaratnam, Greg Collins, Chris Gorman, Ana-Maria Cretu, Simon Tremblay, Marie-Christine Rivard, Catherine Cullwick, Crystal Morris, David G Attwood, Alexandra Baines, Angela Stewart, Stéphane Bouchard, Christopher R Bowie, Synthia Guimond.},

keywords = {adult, article, clinical article, cognitive defect, Cognitive rehabilitation, Cognitive remediation, Cognitive remediation therapy, community functioning, health care personnel, human, neurocognition, patient engagement, program development, psychosis, qualitative research, social cognition, user-centered approach, user-centered design, virtual reality},

pubstate = {published},

tppubtype = {article}

}