Slide
Centre Interdisciplinaire
de Recherche et d’Innovation
en Cybersécurité et Société
de Recherche et d’Innovation
en Cybersécurité et Société
1.
Brideau-Duquette, M.; Côté, S. S. -P.; Boukhalfi, T.; Renaud, P.
Forensic Psychiatry and Big Data: Towards a Cyberphysical System in Service of Clinic, Research and Cybersecurity Article d'actes
Dans: B., Boulay; T., Di Mascio; E., Tovar; C., Meinel (Ed.): International Conference on Computer Supported Education, CSEDU - Proceedings, p. 856–864, Science and Technology Publications, Lda, 2025, ISBN: 21845026 (ISSN); 978-989758746-7 (ISBN), (Journal Abbreviation: International Conference on Computer Supported Education, CSEDU - Proceedings).
Résumé | Liens | BibTeX | Étiquettes: Artificial intelligence, Artificial life, Behavioral research, Computer forensics, Cyber security, Cyber-physical systems, Cyberphysical System, Cybersecurity, Data Lake, Data repositories, Extended Reality, Forensic engineering, Forensic psychiatry, Intelligent computing, prediction, Prevention, Research efforts, Social Engineering, Sociology, System in services
@inproceedings{brideau-duquette_forensic_2025,
title = {Forensic Psychiatry and Big Data: Towards a Cyberphysical System in Service of Clinic, Research and Cybersecurity},
author = {M. Brideau-Duquette and S. S. -P. Côté and T. Boukhalfi and P. Renaud},
editor = {Boulay B. and Di Mascio T. and Tovar E. and Meinel C.},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105003621528&doi=10.5220%2f0013496100003932&partnerID=40&md5=ee442c9113f1104973b40ef698bc5d7d},
doi = {10.5220/0013496100003932},
isbn = {21845026 (ISSN); 978-989758746-7 (ISBN)},
year = {2025},
date = {2025-01-01},
booktitle = {International Conference on Computer Supported Education, CSEDU - Proceedings},
volume = {1},
pages = {856–864},
publisher = {Science and Technology Publications, Lda},
abstract = {The advent of big data and artificial intelligence has led to the elaboration of computational psychiatry. In parallel, great progress has been made with extended reality (XR) technologies. In this article, we propose to build a forensic cyberphysical system (CPS) that, with a data lake as its computational and data repository core, will support clinical and research efforts in forensic psychiatry, this in both intramural and extramural settings. The proposed CPS requires offender's data (notably clinical, behavioural and physiological), but also emphasises the collection of such data in various XR contexts. The same data would be used to train machine and deep learning, artificial intelligence, algorithms. Beyond the direct feedback these algorithms could give to forensic specialists, they could help build forensic digital twins. They could also serve in the fine tuning of XR usage with offenders. This paper concludes with human-centered cybersecurity concerns and opportunities the same CPS would imply. The proximity between a forensic and XR-supported CPS and social engineering will be addressed, and special consideration will be given to the opportunity for situational awareness training with offenders. We conclude by sketching ethical and implementation challenges that would require future inquiring. Copyright © 2025 by SCITEPRESS - Science and Technology Publications, Lda.},
note = {Journal Abbreviation: International Conference on Computer Supported Education, CSEDU - Proceedings},
keywords = {Artificial intelligence, Artificial life, Behavioral research, Computer forensics, Cyber security, Cyber-physical systems, Cyberphysical System, Cybersecurity, Data Lake, Data repositories, Extended Reality, Forensic engineering, Forensic psychiatry, Intelligent computing, prediction, Prevention, Research efforts, Social Engineering, Sociology, System in services},
pubstate = {published},
tppubtype = {inproceedings}
}
The advent of big data and artificial intelligence has led to the elaboration of computational psychiatry. In parallel, great progress has been made with extended reality (XR) technologies. In this article, we propose to build a forensic cyberphysical system (CPS) that, with a data lake as its computational and data repository core, will support clinical and research efforts in forensic psychiatry, this in both intramural and extramural settings. The proposed CPS requires offender's data (notably clinical, behavioural and physiological), but also emphasises the collection of such data in various XR contexts. The same data would be used to train machine and deep learning, artificial intelligence, algorithms. Beyond the direct feedback these algorithms could give to forensic specialists, they could help build forensic digital twins. They could also serve in the fine tuning of XR usage with offenders. This paper concludes with human-centered cybersecurity concerns and opportunities the same CPS would imply. The proximity between a forensic and XR-supported CPS and social engineering will be addressed, and special consideration will be given to the opportunity for situational awareness training with offenders. We conclude by sketching ethical and implementation challenges that would require future inquiring. Copyright © 2025 by SCITEPRESS - Science and Technology Publications, Lda.
2.
Larochelle, S.; Dugas, M. J.; Langlois, F.; Gosselin, P.; Belleville, G.; Bouchard, S.
Intolerance of Uncertainty and Emotion Dysregulation as Predictors of Generalized Anxiety Disorder Severity in a Clinical Population Article de journal
Dans: Journal of Clinical Medicine, vol. 14, no 5, 2025, ISSN: 20770383 (ISSN), (Publisher: Multidisciplinary Digital Publishing Institute (MDPI)).
Résumé | Liens | BibTeX | Étiquettes: adult, aged, article, Beck Depression Inventory, clinical population, comorbidity, controlled study, Depression, difficulties in emotion regulation scale, disease severity, emotion, emotion dysregulation, emotion regulation, employment status, female, generalized anxiety disorder, human, intolerance of uncertainty, Intolerance of Uncertainty Scale, major clinical study, male, patient worry, penn state worry questionnaire, prediction, predictive model, psychotherapy, Severity of Illness Index, sociodemographics, theoretical model
@article{larochelle_intolerance_2025,
title = {Intolerance of Uncertainty and Emotion Dysregulation as Predictors of Generalized Anxiety Disorder Severity in a Clinical Population},
author = {S. Larochelle and M. J. Dugas and F. Langlois and P. Gosselin and G. Belleville and S. Bouchard},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000587548&doi=10.3390%2fjcm14051502&partnerID=40&md5=ea6c43194a821d0a0623385714231936},
doi = {10.3390/jcm14051502},
issn = {20770383 (ISSN)},
year = {2025},
date = {2025-01-01},
journal = {Journal of Clinical Medicine},
volume = {14},
number = {5},
abstract = {Background/objectives: Several factors have been shown to play a role in the development and maintenance of generalized anxiety disorder (GAD), including intolerance of uncertainty and emotion dysregulation. Although the individual contribution of both of these factors is well documented, their combined effect has yet to be studied in a clinical population with GAD. The aim of the present study was to examine the relative contribution of intolerance of uncertainty and emotion dysregulation to the prediction of worry and GAD severity in adults with GAD. Methods: The sample consisted of 108 participants diagnosed with GAD. The participants completed measures of worry, GAD severity, depressive symptoms, intolerance of uncertainty, and emotion dysregulation. Results: Multiple regression indicated that both intolerance of uncertainty and emotion dysregulation significantly contributed to both worry and GAD severity, over and above the contribution of depressive symptoms. Of note, the model explained 36% of the variance in GAD severity scores. Conclusions: The present results provide preliminary evidence of complementarity among dominant models of GAD, and point to the potential role of integrative conceptualizations and treatment strategies for GAD. © 2025 by the authors.},
note = {Publisher: Multidisciplinary Digital Publishing Institute (MDPI)},
keywords = {adult, aged, article, Beck Depression Inventory, clinical population, comorbidity, controlled study, Depression, difficulties in emotion regulation scale, disease severity, emotion, emotion dysregulation, emotion regulation, employment status, female, generalized anxiety disorder, human, intolerance of uncertainty, Intolerance of Uncertainty Scale, major clinical study, male, patient worry, penn state worry questionnaire, prediction, predictive model, psychotherapy, Severity of Illness Index, sociodemographics, theoretical model},
pubstate = {published},
tppubtype = {article}
}
Background/objectives: Several factors have been shown to play a role in the development and maintenance of generalized anxiety disorder (GAD), including intolerance of uncertainty and emotion dysregulation. Although the individual contribution of both of these factors is well documented, their combined effect has yet to be studied in a clinical population with GAD. The aim of the present study was to examine the relative contribution of intolerance of uncertainty and emotion dysregulation to the prediction of worry and GAD severity in adults with GAD. Methods: The sample consisted of 108 participants diagnosed with GAD. The participants completed measures of worry, GAD severity, depressive symptoms, intolerance of uncertainty, and emotion dysregulation. Results: Multiple regression indicated that both intolerance of uncertainty and emotion dysregulation significantly contributed to both worry and GAD severity, over and above the contribution of depressive symptoms. Of note, the model explained 36% of the variance in GAD severity scores. Conclusions: The present results provide preliminary evidence of complementarity among dominant models of GAD, and point to the potential role of integrative conceptualizations and treatment strategies for GAD. © 2025 by the authors.
3.
Ansado, J.; Chasen, C.; Bouchard, S.; Northoff, G.
How brain imaging provides predictive biomarkers for therapeutic success in the context of virtual reality cognitive training Article de journal
Dans: Neuroscience and Biobehavioral Reviews, vol. 120, p. 583–594, 2021, ISSN: 01497634, (Publisher: Elsevier Ltd).
Résumé | Liens | BibTeX | Étiquettes: accuracy, attention deficit disorder, biological monitoring, brain depth stimulation, brain electrophysiology, brain radiography, brain region, cell function, cerebrovascular accident, clinician, cognition, Cognitive rehabilitation, disease marker, electroencephalogram, Electroencephalography, functional magnetic resonance imaging, functional near-infrared spectroscopy, human, image quality, in vivo study, nerve cell, neuroimaging, neurologic disease, neuropsychological test, neuropsychology, neurorehabilitation, nonhuman, prediction, priority journal, review, therapy effect, training, traumatic brain injury, virtual reality, virtual reality cognitive training
@article{ansado_how_2021,
title = {How brain imaging provides predictive biomarkers for therapeutic success in the context of virtual reality cognitive training},
author = {J. Ansado and C. Chasen and S. Bouchard and G. Northoff},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089070480&doi=10.1016%2fj.neubiorev.2020.05.018&partnerID=40&md5=8e5ea676958e050b32a893830dbc2a93},
doi = {10.1016/j.neubiorev.2020.05.018},
issn = {01497634},
year = {2021},
date = {2021-01-01},
journal = {Neuroscience and Biobehavioral Reviews},
volume = {120},
pages = {583–594},
abstract = {As Virtual reality (VR) is increasingly used in neurological disorders such as stroke, traumatic brain injury, or attention deficit disorder, the question of how it impacts the brain's neuronal activity and function becomes essential. VR can be combined with neuroimaging to offer invaluable insight into how the targeted brain areas respond to stimulation during neurorehabilitation training. That, in turn, could eventually serve as a predictive marker for therapeutic success. Functional magnetic resonance imaging (fMRI) identified neuronal activity related to blood flow to reveal with a high spatial resolution how activation patterns change, and restructuring occurs after VR training. Portable and quiet, electroencephalography (EEG) conveniently allows the clinician to track spontaneous electrical brain activity in high temporal resolution. Then, functional near-infrared spectroscopy (fNIRS) combines the spatial precision level of fMRIs with the portability and high temporal resolution of EEG to constitute an ideal measuring tool in virtual environments (VEs). This narrative review explores the role of VR and concurrent neuroimaging in cognitive rehabilitation. © 2020 Elsevier Ltd},
note = {Publisher: Elsevier Ltd},
keywords = {accuracy, attention deficit disorder, biological monitoring, brain depth stimulation, brain electrophysiology, brain radiography, brain region, cell function, cerebrovascular accident, clinician, cognition, Cognitive rehabilitation, disease marker, electroencephalogram, Electroencephalography, functional magnetic resonance imaging, functional near-infrared spectroscopy, human, image quality, in vivo study, nerve cell, neuroimaging, neurologic disease, neuropsychological test, neuropsychology, neurorehabilitation, nonhuman, prediction, priority journal, review, therapy effect, training, traumatic brain injury, virtual reality, virtual reality cognitive training},
pubstate = {published},
tppubtype = {article}
}
As Virtual reality (VR) is increasingly used in neurological disorders such as stroke, traumatic brain injury, or attention deficit disorder, the question of how it impacts the brain's neuronal activity and function becomes essential. VR can be combined with neuroimaging to offer invaluable insight into how the targeted brain areas respond to stimulation during neurorehabilitation training. That, in turn, could eventually serve as a predictive marker for therapeutic success. Functional magnetic resonance imaging (fMRI) identified neuronal activity related to blood flow to reveal with a high spatial resolution how activation patterns change, and restructuring occurs after VR training. Portable and quiet, electroencephalography (EEG) conveniently allows the clinician to track spontaneous electrical brain activity in high temporal resolution. Then, functional near-infrared spectroscopy (fNIRS) combines the spatial precision level of fMRIs with the portability and high temporal resolution of EEG to constitute an ideal measuring tool in virtual environments (VEs). This narrative review explores the role of VR and concurrent neuroimaging in cognitive rehabilitation. © 2020 Elsevier Ltd
4.
Pagé, C. A.; Tourigny, M.; Renaud, P.
Dans: Sexologies, vol. 19, no 2, p. 109–118, 2010, ISSN: 11581360 (ISSN).
Liens | BibTeX | Étiquettes: Adolescent, adult, article, Child, child behavior, comparative study, controlled study, coping behavior, Coping Inventory for Stressful Situation, emotion, female, human, male, peer group, prediction, psychological rating scale, school child, Sexual Behavior, sexual crime, Stress
@article{page_comparative_2010,
title = {A comparative analysis of youth sex offenders and non-offender peers: Is there a difference in their coping strategies? [Analyse comparée d'un groupe de jeunes délinquants sexuels et de jeunes non délinquants sexuels : y a-t-il une différence au niveau de leurs stratégies d'adaptation ?]},
author = {C. A. Pagé and M. Tourigny and P. Renaud},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954501869&doi=10.1016%2fj.sexol.2009.11.001&partnerID=40&md5=ee716e11cfd3716ce582214044fb7bda},
doi = {10.1016/j.sexol.2009.11.001},
issn = {11581360 (ISSN)},
year = {2010},
date = {2010-01-01},
journal = {Sexologies},
volume = {19},
number = {2},
pages = {109–118},
keywords = {Adolescent, adult, article, Child, child behavior, comparative study, controlled study, coping behavior, Coping Inventory for Stressful Situation, emotion, female, human, male, peer group, prediction, psychological rating scale, school child, Sexual Behavior, sexual crime, Stress},
pubstate = {published},
tppubtype = {article}
}
5.
Pagé, C. A.; Tourigny, M.; Renaud, P.
A comparative analysis of youth sex offenders and non-offender peers: Is there a difference in their coping strategies? Article de journal
Dans: Sexologies, vol. 19, no 2, p. 78–86, 2010, ISSN: 11581360 (ISSN).
Résumé | Liens | BibTeX | Étiquettes: Adolescent, Adolescents, adult, article, Child, child psychiatry, comparative study, controlled study, coping behavior, Coping Inventory for Stressful Situation, Coping strategies, emotion, human, male, peer group, prediction, psychological rating scale, school child, Sexual Behavior, sexual crime, Sexual offending, Stress, Youth sexual offenders
@article{page_comparative_2010-1,
title = {A comparative analysis of youth sex offenders and non-offender peers: Is there a difference in their coping strategies?},
author = {C. A. Pagé and M. Tourigny and P. Renaud},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954537963&doi=10.1016%2fj.sexol.2009.11.002&partnerID=40&md5=8bfd0b580c2b08569fa180ec7713b7ca},
doi = {10.1016/j.sexol.2009.11.002},
issn = {11581360 (ISSN)},
year = {2010},
date = {2010-01-01},
journal = {Sexologies},
volume = {19},
number = {2},
pages = {78–86},
abstract = {Purpose: To investigate the coping strategies of youth sexual offenders, which are believed to be important elements in the development of sexual offending behaviours. Subjects and method: This cross-sectional study investigated two groups of male adolescents (n = 196) consisting of youth sexual offenders and non-offender peers. Examination of the coping strategies was measured by a Coping Inventory for Stressful Situations (CISS). Results: It was hypothesized that youth sexual offenders used sex-related activities and emotions as coping strategies to alleviate negative emotional states and problematic situations. The results obtained demonstrated that youth sexual offenders make less use of sex-related activities as a way of coping with stressful situations, but make more use of emotions-coping strategies when compared to non-offender peers. An attempt was made to predict youth as sexual offenders or non-offenders according to the coping strategies they used in times of stress. The logistic regression model used was statistically significant and the analysis performed increased the likelihood of correctly identifying youth sexual offenders based on the coping strategies used in times of stress. Conclusion: The results of the study demonstrated that youth sexual offenders have a tendency to use emotional responses to cope with life's difficulties, which may be increasing their level of stress and thereby placing them at a higher risk to offend sexually. © 2009 Elsevier Masson SAS. All rights reserved.},
keywords = {Adolescent, Adolescents, adult, article, Child, child psychiatry, comparative study, controlled study, coping behavior, Coping Inventory for Stressful Situation, Coping strategies, emotion, human, male, peer group, prediction, psychological rating scale, school child, Sexual Behavior, sexual crime, Sexual offending, Stress, Youth sexual offenders},
pubstate = {published},
tppubtype = {article}
}
Purpose: To investigate the coping strategies of youth sexual offenders, which are believed to be important elements in the development of sexual offending behaviours. Subjects and method: This cross-sectional study investigated two groups of male adolescents (n = 196) consisting of youth sexual offenders and non-offender peers. Examination of the coping strategies was measured by a Coping Inventory for Stressful Situations (CISS). Results: It was hypothesized that youth sexual offenders used sex-related activities and emotions as coping strategies to alleviate negative emotional states and problematic situations. The results obtained demonstrated that youth sexual offenders make less use of sex-related activities as a way of coping with stressful situations, but make more use of emotions-coping strategies when compared to non-offender peers. An attempt was made to predict youth as sexual offenders or non-offenders according to the coping strategies they used in times of stress. The logistic regression model used was statistically significant and the analysis performed increased the likelihood of correctly identifying youth sexual offenders based on the coping strategies used in times of stress. Conclusion: The results of the study demonstrated that youth sexual offenders have a tendency to use emotional responses to cope with life's difficulties, which may be increasing their level of stress and thereby placing them at a higher risk to offend sexually. © 2009 Elsevier Masson SAS. All rights reserved.
6.
Côté, S.; Bouchard, S.
Cognitive mechanisms underlying virtual reality exposure Article de journal
Dans: Cyberpsychology and Behavior, vol. 12, no 2, p. 121–129, 2009, ISSN: 10949313 (ISSN).
Résumé | Liens | BibTeX | Étiquettes: Adaptation, adult, aged, Animals, arachnophobia, Arousal, article, avoidance behavior, cardiovascular response, clinical article, cognition, Culture, female, Heart Rate, human, Humans, Implosive Therapy, male, Middle Aged, Personality Assessment, phobia, Phobic Disorders, prediction, Psychological, questionnaire, Questionnaires, regression analysis, scoring system, Self Efficacy, spider, Spiders, structured interview, task performance, treatment outcome, User-Computer Interface, virtual reality, Young Adult
@article{cote_cognitive_2009,
title = {Cognitive mechanisms underlying virtual reality exposure},
author = {S. Côté and S. Bouchard},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-64749106909&doi=10.1089%2fcpb.2008.0008&partnerID=40&md5=e9bd263ea9e1940b66910d9651bd119e},
doi = {10.1089/cpb.2008.0008},
issn = {10949313 (ISSN)},
year = {2009},
date = {2009-01-01},
journal = {Cyberpsychology and Behavior},
volume = {12},
number = {2},
pages = {121–129},
abstract = {Many studies have assessed virtual reality exposures efficacy, but very few examined its treatment processes. The addition of objective measures of arousal and information processing mechanisms would be a valuable contribution in order to provide a more complete and detailed picture. The goal of this study was to better document the cognitive mechanisms associated with therapeutic change after an in virtuo exposure treatment. Twenty-eight adults suffering from arachnophobia were assessed and received an exposure-based treatment using virtual reality. General outcome and specific processes measures included a battery of standardized questionnaires, a pictorial emotional Stroop task, a Behavioral Avoidance Test, and a measure of participants' cardiac response while they looked at a live tarantula. The analyses showed that changes in perceived self-efficacy and dysfunctional beliefs were the best predictors of change in general outcome and cardiac response; change in dysfunctional beliefs were the best predictor of change in behavioral avoidance. These innovative results provide a very detailed and organized picture of the complex cognitive mechanisms involved in therapeutic change following in virtuo exposure for arachnophobia. © 2009 Mary Ann Liebert, Inc.},
keywords = {Adaptation, adult, aged, Animals, arachnophobia, Arousal, article, avoidance behavior, cardiovascular response, clinical article, cognition, Culture, female, Heart Rate, human, Humans, Implosive Therapy, male, Middle Aged, Personality Assessment, phobia, Phobic Disorders, prediction, Psychological, questionnaire, Questionnaires, regression analysis, scoring system, Self Efficacy, spider, Spiders, structured interview, task performance, treatment outcome, User-Computer Interface, virtual reality, Young Adult},
pubstate = {published},
tppubtype = {article}
}
Many studies have assessed virtual reality exposures efficacy, but very few examined its treatment processes. The addition of objective measures of arousal and information processing mechanisms would be a valuable contribution in order to provide a more complete and detailed picture. The goal of this study was to better document the cognitive mechanisms associated with therapeutic change after an in virtuo exposure treatment. Twenty-eight adults suffering from arachnophobia were assessed and received an exposure-based treatment using virtual reality. General outcome and specific processes measures included a battery of standardized questionnaires, a pictorial emotional Stroop task, a Behavioral Avoidance Test, and a measure of participants' cardiac response while they looked at a live tarantula. The analyses showed that changes in perceived self-efficacy and dysfunctional beliefs were the best predictors of change in general outcome and cardiac response; change in dysfunctional beliefs were the best predictor of change in behavioral avoidance. These innovative results provide a very detailed and organized picture of the complex cognitive mechanisms involved in therapeutic change following in virtuo exposure for arachnophobia. © 2009 Mary Ann Liebert, Inc.
7.
Maziade, M.; Bouchard, S.; Gingras, N.; Charron, L.; Cardinal, A.; Roy, M. -A.; Gauthier, B.; Tremblay, G.; Côté, S.; Fournier, C.; Boutin, P.; Hamel, M.; Mérette, C.; Martinez, M.
Dans: British Journal of Psychiatry, vol. 169, no 3, p. 371–378, 1996, ISSN: 00071250, (Publisher: Royal College of Psychiatrists).
Résumé | Liens | BibTeX | Étiquettes: Adolescent, adult, article, behavior disorder, Child, Childhood, clinical article, Delusions, Depression, developmental disorder, disease course, female, Follow-Up Studies, Hallucinations, human, Humans, male, negative syndrome, onset age, Personality Development, prediction, Psychiatric Status Rating Scales, Risk Factors, schizophrenia, Schizophrenic Psychology, Schizotypal Personality Disorder
@article{maziade_long-term_1996,
title = {Long-term stability of diagnosis and symptom dimensions in a systematic sample of patients with onset of Schizophrenia in childhood and early adolescence. II: Positive/negative distinction and childhood predictors of adult outcome},
author = {M. Maziade and S. Bouchard and N. Gingras and L. Charron and A. Cardinal and M. -A. Roy and B. Gauthier and G. Tremblay and S. Côté and C. Fournier and P. Boutin and M. Hamel and C. Mérette and M. Martinez},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029759147&doi=10.1192%2fbjp.169.3.371&partnerID=40&md5=0b5ff36c812ac906915bb5d12769135d},
doi = {10.1192/bjp.169.3.371},
issn = {00071250},
year = {1996},
date = {1996-01-01},
journal = {British Journal of Psychiatry},
volume = {169},
number = {3},
pages = {371–378},
abstract = {Background. The aim of this study was to verify the presence and stability across life of the positive/negative distinction in early-onset schizophrenia (EO-SZ) through a longitudinal factor analysis of the schizophrenic dimensions, and to identify the factors predicting several indices of long-term outcome for EO-SZ. Method. Forty children consecutively referred for DSM-III-R schizophrenia (SZ) in a specific catchment area comprised the sample. Results. Across a 14.8-year follow-up, longitudinal factor analysis identified two separate factors corresponding to the positive and negative symptom dimensions. We also observed that: the GAS rated over the last three years of adult illness and the severity of negative symptoms during the stabilised interepisode intervals in adulthood were the indices of adult outcome that were most easily predicted; and the best childhood predictors of adult outcome were premorbid functioning and severity of positive and negative symptoms during acute episodes. Conclusions. The presence of premorbid non-psychotic behaviour disturbances (NPBD) and premorbid developmental problems was not related to severity of outcome, in contrast to the former variables.},
note = {Publisher: Royal College of Psychiatrists},
keywords = {Adolescent, adult, article, behavior disorder, Child, Childhood, clinical article, Delusions, Depression, developmental disorder, disease course, female, Follow-Up Studies, Hallucinations, human, Humans, male, negative syndrome, onset age, Personality Development, prediction, Psychiatric Status Rating Scales, Risk Factors, schizophrenia, Schizophrenic Psychology, Schizotypal Personality Disorder},
pubstate = {published},
tppubtype = {article}
}
Background. The aim of this study was to verify the presence and stability across life of the positive/negative distinction in early-onset schizophrenia (EO-SZ) through a longitudinal factor analysis of the schizophrenic dimensions, and to identify the factors predicting several indices of long-term outcome for EO-SZ. Method. Forty children consecutively referred for DSM-III-R schizophrenia (SZ) in a specific catchment area comprised the sample. Results. Across a 14.8-year follow-up, longitudinal factor analysis identified two separate factors corresponding to the positive and negative symptom dimensions. We also observed that: the GAS rated over the last three years of adult illness and the severity of negative symptoms during the stabilised interepisode intervals in adulthood were the indices of adult outcome that were most easily predicted; and the best childhood predictors of adult outcome were premorbid functioning and severity of positive and negative symptoms during acute episodes. Conclusions. The presence of premorbid non-psychotic behaviour disturbances (NPBD) and premorbid developmental problems was not related to severity of outcome, in contrast to the former variables.