@article{doney_chronic_2024,

title = {Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions},

author = {E. Doney and L. Dion-Albert and F. Coulombe-Rozon and N. Osborne and R. Bernatchez and S. E. J. Paton and F. N. Kaufmann and R. O. Agomma and J. L. Solano and R. Gaumond and K. A. Dudek and J. K. Szyszkowicz and F. Aardema and L. A. Bentaleb and J. Beauchamp and H. Bendahmane and E. Benoit and L. Bergeron and A. Bertone and N. Bertrand and F. -A. Berube and P. Blanchet and J. Boissonneault and C. J. Bolduc and J. -P. Bonin and F. Borgeat and R. Boyer and C. Breault and J. -J. Breton and C. Briand and J. Brodeur and K. Brule and L. Brunet and S. Carriere and C. Chartrand and R. Chenard-Soucy and T. Chevrette and E. Cloutier and R. Cloutier and H. Cormier and G. Cote and J. Cyr and P. David and L. De Benedictis and M. -C. Delisle and P. Deschenes and C. D. Desjardins and G. Desmarais and J. -L. Dubreucq and M. Dumont and A. Dumais and G. Ethier and C. Feltrin and A. Felx and H. Findlay and L. Fortier and D. Fortin and L. Fortin and N. Francois and V. Gagne and M. -P. Gagnon and M. -C. Gignac-Hens and C. -E. Giguere and R. Godbout and C. Grou and S. Guay and F. Guillem and N. Hachimi-Idrissi and C. Herry and S. Hodgins and S. Homayoun and B. Jemel and C. Joyal and E. Kouassi and R. Labelle and D. Lafortune and M. Lahaie and S. Lahlafi and P. Lalonde and P. Landry and V. Lapaige and G. Larocque and C. Larue and M. Lavoie and J. -J. Leclerc and T. Lecomte and C. Lecours and L. Leduc and M. -F. Lelan and A. Lemieux and A. Lesage and A. Letarte and J. Lepage and A. Levesque and O. Lipp and D. Luck and S. Lupien and F. -A. Lusignan and R. Lusignan and A. J. Luyet and A. Lynhiavu and J. -P. Melun and C. Morin and L. Nicole and F. Noel and L. Normandeau and K. O'Connor and C. Ouellette and V. Parent and M. -H. Parizeau and J. -F. Pelletier and J. Pelletier and M. Pelletier and P. Plusquellec and D. Poirier and S. Potvin and G. Prevost and M. -J. Prevost and P. Racicot and M. -F. Racine-Gagne and P. Renaud and N. Ricard and S. Rivet and M. Rolland and M. Sasseville and G. Safadi and S. Smith and N. Smolla and E. Stip and J. Teitelbaum and A. Thibault and L. Thibault and S. Thibault and F. Thomas and C. Todorov and V. Tourjman and C. Tranulis and S. Trudeau and G. Trudel and N. Vacri and L. Valiquette and C. Vanier and K. Villeneuve and M. Villeneuve and P. Vincent and M. Wolfe and L. Xiong and A. Zizzi and M. Lebel and A. Doyen and A. Durand and F. Lavoie-Cardinal and M. -C. Audet and C. Menard and Cecile Lepage on behalf of Signature Consortium},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162172419&doi=10.1016%2fj.bpsgos.2023.04.007&partnerID=40&md5=aae4250eee5bd708599126cf76c3f5d7},

doi = {10.1016/j.bpsgos.2023.04.007},

issn = {26671743 (ISSN)},

year  = {2024},

date = {2024-01-01},

journal = {Biological Psychiatry Global Open Science},

volume = {4},

number = {1},

pages = {213–228},

abstract = {Background: Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain barrier integrity; still, little is known about intestinal barrier function in these conditions, particularly for the small intestine, where absorption of most foods and drugs takes place. Methods: We investigated how chronic social or variable stress, two mouse models of depression, impact the jejunum intestinal barrier in males and females. Mice were subjected to stress paradigms followed by analysis of gene expression profiles of intestinal barrier–related targets, fecal microbial composition, and blood-based markers. Results: Altered microbial populations and changes in gene expression of jejunum tight junctions were observed depending on the type and duration of stress, with sex-specific effects. We used machine learning to characterize in detail morphological tight junction properties, identifying a cluster of ruffled junctions in stressed animals. Junctional ruffling is associated with inflammation, so we evaluated whether lipopolysaccharide injection recapitulates stress-induced changes in the jejunum and observed profound sex differences. Finally, lipopolysaccharide-binding protein, a marker of gut barrier leakiness, was associated with stress vulnerability in mice, and translational value was confirmed on blood samples from women with MDD. Conclusions: Our results provide evidence that chronic stress disrupts intestinal barrier homeostasis in conjunction with the manifestation of depressive-like behaviors in a sex-specific manner in mice and, possibly, in human depression. © 2023 The Authors},

note = {Publisher: Elsevier Inc.},

keywords = {animal experiment, animal model, animal tissue, article, chronic social defeat, chronic stress, chronic variable stress, claudin 3, Claudins, controlled study, corticosterone, corticosterone blood level, Cytokines, enzyme linked immunosorbent assay, female, human, immunohistochemistry, intestine flora, jejunum, lipopolysaccharide, lipopolysaccharide binding protein, Machine learning, major depression, male, mouse, nonhuman, pathogenesis, protein expression, real time polymerase chain reaction, sex difference, sex differences, social stress, tight junction, Variable stress},

pubstate = {published},

tppubtype = {article}

}

@article{belleville_psychological_2021,

title = {Psychological Symptoms Among Evacuees From the 2016 Fort McMurray Wildfires: A Population-Based Survey One Year Later},

author = {G. Belleville and M. -C. Ouellet and J. Lebel and S. Ghosh and C. M. Morin and S. Bouchard and S. Guay and N. Bergeron and T. Campbell and F. P. MacMaster},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105988601&doi=10.3389%2ffpubh.2021.655357&partnerID=40&md5=4971ac1ba23f88f8b6fa132caed4785d},

doi = {10.3389/fpubh.2021.655357},

issn = {22962565},

year  = {2021},

date = {2021-01-01},

journal = {Frontiers in Public Health},

volume = {9},

abstract = {Background: The 2016 wildfires in Fort McMurray (Alberta, Canada) led to a massive displacement of 88,000 people and destroyed 2,400 homes. Although no direct human fatality resulted, many individuals feared for their lives or those of their loved ones. Objectives: (1) To estimate the prevalence of post-traumatic stress, major depressive, insomnia, generalized anxiety, and substance use disorders in the adult population of Fort McMurray 1 year after the evacuation; (2) To identify pre-, peri-, and post-disaster correlates of mental health disorders. Methods: A phone survey using random digit sampling was used to survey evacuees. A total of 1,510 evacuees (response rate = 40.2%, 55.5% women, mean age = 44.11},

note = {Publisher: Frontiers Media S.A.},

keywords = {adult, Alberta, Anxiety disorder, Anxiety Disorders, Depressive Disorder, female, human, Humans, Major, major depression, male, Post-Traumatic, posttraumatic stress disorder, Stress Disorders, wildfire, Wildfires},

pubstate = {published},

tppubtype = {article}

}

@article{maiano_prevalence_2018,

title = {Prevalence of anxiety and depressive disorders among youth with intellectual disabilities: A systematic review and meta-analysis},

author = {C. Maïano and S. Coutu and D. Tracey and S. Bouchard and G. Lepage and A. J. S. Morin and G. Moullec},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046664327&doi=10.1016%2fj.jad.2018.04.029&partnerID=40&md5=504c552402432a5b6443d07f63170403},

doi = {10.1016/j.jad.2018.04.029},

issn = {01650327},

year  = {2018},

date = {2018-01-01},

journal = {Journal of Affective Disorders},

volume = {236},

pages = {230–242},

abstract = {Background: The purpose of this meta-analytic study was to determine the pooled prevalence estimates of anxiety and depressive disorders among children and adolescents with intellectual disabilities (ID) and to assess the extent to which these pooled prevalence rates differed according to studies’ characteristics. Method: A systematic literature search was performed in nine databases and 21 studies, published between 1975 and 2015, met the inclusion criteria. Results: The resulting pooled prevalence estimates of combined subtypes of anxiety and depressive disorders were respectively (a) 5.4% and 2.8% across samples; (b) 1.2% and 0.03% among children; and (c) 7.9% and 1.4% among adolescents. Pooled prevalence estimates for specific subtypes of anxiety disorders ranged from (a) 0.2% to 11.5% across samples; (b) 0.7% to 17.6% among children; and (c) 0.6% to 19.8% among adolescents. Pooled prevalence estimates of dysthymic disorder and major depressive disorder were respectively (a) 3.4% and 2.5% across samples; (b) 2.1% and 3.2% among children; and (c) 6.9% and 5.7% among adolescents. Finally, subgroup analyses showed significant variations in the pooled prevalence estimates of combined subtypes of anxiety disorders, obsessive-compulsive disorder, and generalized anxiety disorder; and combined subtypes of depressive disorders. Limitations: The present findings of this meta-analysis should be interpreted with caution given several limitations related to the characteristics of the populations, diagnostic method and sampling method. Conclusion: Findings provide recommendations for future studies investigating psychological disorders among youth with ID, as well as how clinicians and policy makers can improve diagnostic practices and support for youth with ID. © 2018 Elsevier B.V.},

note = {Publisher: Elsevier B.V.},

keywords = {Adolescent, adolescent disease, Anxiety disorder, Anxiety Disorders, Child, childhood disease, Depression, Depressive Disorder, dysthymia, Dysthymic Disorder, female, generalized anxiety disorder, human, Humans, infant, Intellectual Disability, intellectual impairment, Major, major depression, male, meta analysis, Newborn, obsessive compulsive disorder, Obsessive-Compulsive Disorder, Preschool, preschool child, Prevalence, priority journal, psychology, review, systematic review, Young Adult},

pubstate = {published},

tppubtype = {article}

}

@article{ikic_reduction_2017,

title = {Reduction in costs after treating comorbid panic disorder with agoraphobia and generalized anxiety disorder},

author = {V. Ikic and C. Bélanger and S. Bouchard and P. Gosselin and F. Langlois and J. Labrecque and M. J. Dugas and A. Marchand},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018690998&partnerID=40&md5=0d0600e6dd4e2a381f733ac063d639dc},

issn = {10914358},

year  = {2017},

date = {2017-01-01},

journal = {Journal of Mental Health Policy and Economics},

volume = {20},

number = {1},

pages = {11–20},

abstract = {Background: Panic disorder with agoraphobia (PDA) and generalized anxiety disorder (GAD) are impairing and costly disorders that are often misdiagnosed and left untreated despite multiple consultations. These disorders frequently co-occur, but little is known about the costs associated with their comorbidity and the impact of cognitive-behavioral therapy (CBT) on cost reduction. Aims of the Study: The first objective of this study was to assess the mental health-related costs associated with the specific concomitance of PDA and GAD. The second aim was to determine whether there is a reduction in direct and indirect mental healthrelated costs following conventional CBT for the primary disorder only (PDA or GAD) or combined CBT adapted to the comorbidity (PDA and GAD). Methods: A total of 123 participants with a double diagnosis of PDA and GAD participated in this study. Direct and indirect mental health-related costs were assessed and calculated from a societal perspective at the pre-Test, the post-Test, and the three-month, sixmonth and one-year follow-ups. Results: At the pre-Test, PDA-GAD comorbidity was found to generate a mean total cost of CAD2,000.48 (SD = 2,069.62) per participant over a three-month period. The indirect costs were much higher than the direct costs. Both treatment modalities led to significant and similar decreases in all cost categories from the pretest to the post-Test. This reduction was maintained until the oneyear follow-up. Discussion: Methodological choices may have underestimated cost evaluations. Nonetheless, this study supports the cost offset effects of both conventional CBT for primary PDA or GAD and combined CBT for PDA-GAD comorbidity. Implications for Healthcare Provision and Use: Treatment of comorbid and costly disorders with evidence-based treatments such as CBT may lead to considerable economic benefits for society. Implications for Health Policies: Considering the limited resources of healthcare systems, it is important to make choices that will lead to better accessibility of quality services. The application of CBT for PDA, GAD or both disorders and training mental health professionals in this therapeutic approach should be encouraged. Additionally, it would be favorable for insurance plans to reimburse employees for expenses associated with psychological treatment for anxiety disorders. Implications for Further Research: In addition to symptom reduction, it would be of great pertinence to explore which factors can contribute to reducing direct and indirect mental health-related costs. © 2017 ICMPE.},

note = {Publisher: ICMPE},

keywords = {adult, agoraphobia, Anxiety disorder, Anxiety Disorders, article, cognitive behavioral therapy, cognitive therapy, comorbidity, controlled study, dysthymia, economics, female, follow up, generalized anxiety disorder, health care cost, Health Care Costs, human, Humans, major clinical study, major depression, male, Mental health, obsessive compulsive disorder, panic, Panic Disorder, phobia, posttraumatic stress disorder, procedures, Quebec, social phobia, statistics and numerical data},

pubstate = {published},

tppubtype = {article}

}

@article{yuen_acceptance_2013,

title = {Acceptance based behavior therapy for social anxiety disorder through videoconferencing},

author = {E. K. Yuen and J. D. Herbert and E. M. Forman and E. M. Goetter and A. S. Juarascio and S. Rabin and C. Goodwin and S. Bouchard},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879799248&doi=10.1016%2fj.janxdis.2013.03.002&partnerID=40&md5=a280b967176db691df32f37d15cb52a1},

doi = {10.1016/j.janxdis.2013.03.002},

issn = {18737897 (ISSN)},

year  = {2013},

date = {2013-01-01},

journal = {Journal of Anxiety Disorders},

volume = {27},

number = {4},

pages = {389–397},

abstract = {Most individuals with social anxiety disorder (SAD) do not receive any type of treatment. Reasons include logistical barriers (e.g., geographic location, travel time), fear of stigmatization, and fear of the social interactions associated with seeking treatment. Videoconferencing technology holds great promise in the widespread delivery of evidence-based treatments to those who would otherwise not receive treatment. This pilot study assessed the feasibility, acceptability, and initial efficacy of an acceptance-based behavioral intervention using Skype videoconferencing to treat adults with generalized SAD. Twenty-four participants received 12 sessions of weekly therapy and were assessed at pre-treatment, mid-treatment, post-treatment, and 3-month follow-up. Participants and therapists rated the intervention as acceptable and feasible. Analyses revealed significant pre-treatment to follow-up improvements in social anxiety, depression, disability, quality of life, and experiential avoidance, with effect sizes comparable to or larger than previously published results of studies delivering in-person CBT for SAD. Implications and future directions are discussed. © 2013 Elsevier Ltd.},

keywords = {acceptance based behavior therapy, adult, agoraphobia, alcoholism, article, avoidance behavior, Beck Depression Inventory, behavior therapy, Behavioral Assessment Test, Brief Version of the Fear of Negative Evaluation Scale, clinical article, clinical trial, comorbidity, disability, effect size, Feasibility Studies, feasibility study, female, follow up, Follow-Up Studies, generalized anxiety disorder, human, Humans, interview, Liebowitz Social Anxiety Scale, major depression, male, named inventories, panic, patient attitude, Patient Satisfaction, phobia, Phobic Disorders, Pilot Projects, pilot study, procedures, Psychiatric Status Rating Scales, psychologic test, Psychological, psychological rating scale, psychotherapist attitude, quality of life, questionnaires and rating scales, Skype, social anxiety, social phobia, Social Phobia and Anxiety Inventory, Structured Clinical Interview for DSM Disorders, telehealth, Telemedicine, Telemental health, Telepsychology, treatment outcome, videoconferencing},

pubstate = {published},

tppubtype = {article}

}